Mauritianin
Based on 1 Customer Validation
Mauritianin is an orally active kaempferol glycoside. Mauritianin can be isolated from the flowers and leaves of Acalypha indica. Mauritianin is a topoisomerase I inhibitor. Mauritianin has hepatoprotective, neuroprotective, and renoprotective activities. Mauritianin increases vascular tone when used in combination with Alcesefoliside (HY-N5049).
For research use only. We do not sell to patients.
- Purity: 99.83%
- CAS No.: 109008-28-8
- Formula: C33H40O19
- Molecular Weight:740.66
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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All Topoisomerase Isoforms
More
Biological Activity
Topoisomerase I[2]
Mauritianin (1-100 μM) stabilizes the DNA-topoisomerase I covalent binary complex[2].
Mauritianin (10 μM) alone has no significant effect on the vascular tone of rat basilaris artery segments, but increases vascular tone when combined with Alcesefoliside (HY-N5049)[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Wistar rats (200-250 g) with CCl4-induced liver damage[4]
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Dosage:10 mg/kg
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Administration:Oral administration, 7 days of pretreatment followed by 14 days of curative treatment
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Result:Reduced malondialdehyde (MDA) production by 22%, preserved reduced glutathione (GSH) levels by 32%, and maintained ethylmorphine-N-demethylase (EMND) activity by 20% compared to CCl4-treated group.
Showed well-preserved liver, brain and kidney histoarchitecture with minimal lesions.
Chemical Information
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CAS No. 109008-28-8
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Appearance Solid
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Molecular Weight 740.66
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Formula C33H40O19
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Color Off-white to yellow
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SMILES
O=C1C(O[C@H]2[C@@H]([C@H]([C@@H](O)[C@@H](CO[C@H]3[C@@H]([C@@H]([C@@H](O)[C@H](C)O3)O)O)O2)O)O[C@@]4([H])[C@@H]([C@@H]([C@@H](O)[C@H](C)O4)O)O)=C(C5=CC=C(O)C=C5)OC6=CC(O)=CC(O)=C61
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 100 mg/mL (135.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.38 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (284 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Nahrstedt A, et al. Flavonoids from Acalypha indica. Fitoterapia. 2006 Sep;77(6):484-6. [Content Brief]
[2]. Ma J, et al. DNA topoisomerase I inhibitors from Rinorea anguifera. Bioorg Med Chem Lett. 2005 Feb 1;15(3):813-6. [Content Brief]
[4]. Manov V, et al. In vivo protective effects of Mauritianin. 2023.
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.3501 mL | 6.7507 mL | 13.5015 mL | 33.7537 mL |
| 5 mM | 0.2700 mL | 1.3501 mL | 2.7003 mL | 6.7507 mL | |
| 10 mM | 0.1350 mL | 0.6751 mL | 1.3501 mL | 3.3754 mL | |
| 15 mM | 0.0900 mL | 0.4500 mL | 0.9001 mL | 2.2502 mL | |
| 20 mM | 0.0675 mL | 0.3375 mL | 0.6751 mL | 1.6877 mL | |
| 25 mM | 0.0540 mL | 0.2700 mL | 0.5401 mL | 1.3501 mL | |
| 30 mM | 0.0450 mL | 0.2250 mL | 0.4500 mL | 1.1251 mL | |
| 40 mM | 0.0338 mL | 0.1688 mL | 0.3375 mL | 0.8438 mL | |
| 50 mM | 0.0270 mL | 0.1350 mL | 0.2700 mL | 0.6751 mL | |
| 60 mM | 0.0225 mL | 0.1125 mL | 0.2250 mL | 0.5626 mL | |
| 80 mM | 0.0169 mL | 0.0844 mL | 0.1688 mL | 0.4219 mL | |
| 100 mM | 0.0135 mL | 0.0675 mL | 0.1350 mL | 0.3375 mL |
Mauritianin Related Classifications
HY-N5038 Related Classifications
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