1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. IAXO-102

IAXO-102 

Cat. No.: HY-125171 Purity: >98.0%
Handling Instructions

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.

For research use only. We do not sell to patients.

IAXO-102 Chemical Structure

IAXO-102 Chemical Structure

CAS No. : 1115270-63-7

Size Price Stock Quantity
5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1].

IC50 & Target[1]

TLR4

 

Molecular Weight

585.94

Formula

C₃₅H₇₁NO₅

CAS No.

1115270-63-7

SMILES

CCCCCCCCCCCCCCO[[email protected]@H]1[[email protected]]([[email protected]@H]([[email protected]@H](CN)O[[email protected]@H]1OC)O)OCCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7067 mL 8.5333 mL 17.0666 mL
5 mM 0.3413 mL 1.7067 mL 3.4133 mL
10 mM 0.1707 mL 0.8533 mL 1.7067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
IAXO-102
Cat. No.:
HY-125171
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