1. Immunology/Inflammation
  2. Toll-like Receptor (TLR)
  3. IAXO-102

IAXO-102 

Cat. No.: HY-125171 Purity: >98.0%
Handling Instructions

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development.

For research use only. We do not sell to patients.

IAXO-102 Chemical Structure

IAXO-102 Chemical Structure

CAS No. : 1115270-63-7

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5 mg USD 350 In-stock
Estimated Time of Arrival: December 31
10 mg USD 550 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2650 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflammatory protein. IAXO-102 also prevents experimental abdominal aortic aneurysm development[1].

IC50 & Target[1]

TLR4

 

In Vitro

IAXO-102 (1-10 µM, for 2 hours) inhibits MAPK and p65 NF-κB phosphorylation in human umbilical vein endothelial (HUVEC) cells[1].
IAXO-102 (10 µM, for 17 hours) suppresses LPS induced proinflammatory proteins MCP-1 and IL-8 production in HUVEC[1].

Western Blot Analysis[1]

Cell Line: Human umbilical vein endothelial (HUVEC) cells
Concentration: 1-10 µM
Incubation Time: Pretreatment for 1 hour and then exposed to LPS (100 ng/mL) for additional 1 hour
Result: Significantly inhibited LPS-stimulated MAPK/p65nF-ΚB phosphorylation.
In Vivo

IAXO-102 (3 mg/kg/day, s.c. for 28 days) significantly retards Angiotensin II induced increase in aortic diameter in mice[1].

Animal Model: Six-monthold ApoE−/−/C57Bl6[1]
Dosage: 3 mg/kg/day
Administration: S.C. for 28 days
Result: Significantly retarded Angiotensin II-induced increase in aortic diameter.
Molecular Weight

585.94

Formula

C₃₅H₇₁NO₅

CAS No.

1115270-63-7

SMILES

CCCCCCCCCCCCCCO[[email protected]@H]1[[email protected]]([[email protected]@H]([[email protected]@H](CN)O[[email protected]@H]1OC)O)OCCCCCCCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 50 mg/mL (85.33 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7067 mL 8.5333 mL 17.0666 mL
5 mM 0.3413 mL 1.7067 mL 3.4133 mL
10 mM 0.1707 mL 0.8533 mL 1.7067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.42 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

IAXO-102IAXO102IAXO 102Toll-like Receptor (TLR)Inhibitorinhibitorinhibit

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Product name:
IAXO-102
Cat. No.:
HY-125171
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