1. Immunology/Inflammation
    NF-κB
  2. Toll-like Receptor (TLR)
    NF-κB
  3. Okanin

Okanin 

Cat. No.: HY-N6673
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Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways.

For research use only. We do not sell to patients.

Okanin Chemical Structure

Okanin Chemical Structure

CAS No. : 484-76-4

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Description

Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1].

IC50 & Target[1]

TLR4

 

p65

 

In Vitro

Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].

Molecular Weight

288.25

Formula

C₁₅H₁₂O₆

CAS No.

484-76-4

SMILES

O=C(C1=CC=C(O)C(O)=C1O)/C=C/C2=CC=C(O)C(O)=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Okanin
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HY-N6673
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