520-18-3
520-18-3
Chemical Structure
Kaempferol
Synonym(s): Kempferol; Robigenin
- CAS No.: 520-18-3
- Formula:C15H10O6
- Molecular Weight:286.24
IUPAC Name: 3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
InChIKey: IYRMWMYZSQPJKC-UHFFFAOYSA-N
SMILES: OC1=C2C(OC(C3=CC=C(O)C=C3)=C(O)C2=O)=CC(O)=C1
Biological Activity: Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer[1][2][3][4].
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Kaempferol | 99.84% | Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer. | ||||||||||||||||||||
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Kaempferol (Standard) | 99.80% | Kaempferol (Standard) is the analytical standard of Kaempferol. This product is intended for research and analytical applications. Kaempferol (Kempferol), a flavonoid found in many edible plants, inhibits estrogen receptor α expression in breast cancer cells and induces apoptosis in glioblastoma cells and lung cancer cells by activation of MEK-MAPK. Kaempferol can be uesd for the research of breast cancer. | ||||||||||||||||||||
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6-Hydroxykaempferol | 99.22% | 6-Hydroxykaempferol, a flavonoid, is a competitive tyrosinase inhibitor with an IC50 value of 124 μM. 6-Hydroxykaempferol has a Ki value of 148 μM relative to L-DOPA as a substrate and effectively inhibits the activity of the enzyme by binding to the active site of the enzyme. | ||||||||||||||||||||
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Kaempferide (Standard) | 98.08% | Kaempferide (Standard) is the analytical standard of Kaempferide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Quercetin (Standard) | 99.64% | Quercetin (Standard) is the analytical standard of Quercetin. This product is intended for research and analytical applications. Quercetin, a natural flavonoid, is a stimulator of recombinant SIRT1 and also a PI3K inhibitor with IC50 of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. | ||||||||||||||||||||
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Quercetin dihydrate (Standard) | 96.64% | Quercetin (dihydrate) (Standard) is the analytical standard of Quercetin (dihydrate). This product is intended for research and analytical applications. Quercetin dihydrate, a natural flavonoid, is a stimulator of recombinant SIRT1 and a PI3K inhibitor with IC50s of 2.4 μM, 3.0 μM and 5.4 μM for PI3K γ, PI3K δ and PI3K β, respectively. | ||||||||||||||||||||
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Galangin | 99.99% | Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity. | ||||||||||||||||||||
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Galangin-13C3 | Galangin-13C3 is the 13C-labeled Galangin. Galangin (Norizalpinin) is an agonist/antagonist of the arylhydrocarbon receptor. Galangin (Norizalpinin) also shows inhibition of CYP1A1 activity. | |||||||||||||||||||||
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Morin (Standard) | ≥98% | Morin (Standard) is the analytical standard of Morin. This product is intended for research and analytical applications. Morin, a plant-derived flavonoid, possesses low antioxidant activity. Morin is a fluorescing chelating agent used in aluminum speciation. | ||||||||||||||||||||
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Kaempferol 5-methyl ether | Kaempferol 5-methyl ether (5-O-Methylkaempferol) is a flavonoid compound. Kaempferol 5-methyl ether can be isolated from the geopropolis of Melipona subnitida. | |||||||||||||||||||||
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Rhamnocitrin (Standard) | ≥98% | Rhamnocitrin (Standard) is the analytical standard of Rhamnocitrin. This product is intended for research and analytical applications. Rhamnocitrin is an anti-inflammatory and antioxidant agent that targets STIM-1, NFATc3 and MAPK pathways and can scavenge DPPH (IC50=28.38 mM). Rhamnocitrin selectively inhibits oxidative stress and inflammatory responses in vascular endothelial cells and neurons. Rhamnocitrin up-regulates miR-185 to inhibit STIM-1-mediated store-operated calcium entry (SOCE), thereby blocking NFATc3 nuclear translocation and downstream inflammatory factor expression, while inducing heme oxygenase HO-1 expression and regulating the ERK/p38 MAPK pathway, inhibiting antioxidant and pro-inflammatory cytokines (such as IL-6, IL-8) and adhesion molecules (such as ICAM-1, VCAM-1). Rhamnocitrin can be used in the study of endothelial-related inflammatory diseases (such as sepsis, acute lung injury, atherosclerosis) and neuroprotection (such as oxidative damage of PC12 cells). | ||||||||||||||||||||
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Isokaempferide | 99.88% | Isokaempferide is a flavonoid can be isolated from the aerial parts of Genista ephedroides. | ||||||||||||||||||||
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References
- [1]. Luo H, et al. Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability. Int J Nanomedicine. 2012; 7: 3951-3959. [Content Brief]
- [2]. Luo H, et al. Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway. Food Chem. 2011 September 15; 128(2): 513-519. [Content Brief]
- [3]. An M, et al. Protective effects of Kaempferol against cardiac sinus node dysfunction via CaMKII deoxidization. Anat Cell Biol. 2015 Dec;48(4):235-43. [Content Brief]
- [4]. Shin D, et al. Dietary Compound Kaempferol Inhibits Airway Thickening Induced by Allergic Reaction in a Bovine Serum Albumin-Induced Model of Asthma. Int J Mol Sci. 2015 Dec 16;16(12):29980-95. [Content Brief]
