Bridged androstenediol analogs as ER-beta selective SERMs

  • Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053.
Timothy A Blizzard  1 ,  Candido Gude ,  Wanda Chan ,  Elizabeth T Birzin ,  Marina Mojena ,  Consuelo Tudela ,  Fang Chen ,  Kristin Knecht ,  Qin Su ,  Bryan Kraker ,  Mark A Holmes ,  Susan P Rohrer ,  Milton L Hammond
Affiliations
PMID: 17448656 DOI: 10.1016/j.bmcl.2006.12.053
Abstract

A series of bridged androstenediol derivatives was prepared. The bridged compounds exhibited reduced ER-beta selectivity relative to uncyclized analogs.