Androstenediol analogs as ER-beta-selective SERMs

  • Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014.
Timothy A Blizzard  1 ,  Candido Gude ,  Jerry D Morgan 2nd ,  Wanda Chan ,  Elizabeth T Birzin ,  Marina Mojena ,  Consuelo Tudela ,  Fang Chen ,  Kristin Knecht ,  Qin Su ,  Bryan Kraker ,  Ralph T Mosley ,  Mark A Holmes ,  Nandini Sharma ,  Paula M D Fitzgerald ,  Susan P Rohrer ,  Milton L Hammond
Affiliations
PMID: 16309907 DOI: 10.1016/j.bmcl.2005.11.014
Abstract

A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.