Estradiol cypionate
Based on 12 publication(s) in Google Scholar
Estradiol cypionate is the 17β-cypionate ester of Estradiol, which inhibits ET-1 synthesis by acting on estrogen receptors.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- Reinheit: 99.47%
- CAS. Nr.: 313-06-4
- Formel: C26H36O3
- Molecular Weight:396.56
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Speicherung:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Chemical Information
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Publications Citing Use of MedChemExpress (MCE) Estradiol cypionate
More- J Hematol Oncol. 2019 Feb 22;12(1):19. [Abstract]
- J Exp Clin Cancer Res. 2020 May 7;39(1):81. [Abstract]
- Biomaterials. 2018 Aug;173:58-70. [Abstract]
- Cell Death Dis. 2025 May 19;16(1):403. [Abstract]
- Cell Death Dis. 2017 May 11;8(5):e2783. [Abstract]
- Phytomedicine. 2023 Dec:121:155054. [Abstract]
- Int J Mol Sci. 2024 Mar 18;25(6):3424. [Abstract]
- Mol Med Rep. 2022 Jan;25(1):15. [Abstract]
- Gland Surg. 2021 Aug;10(8):2414-2427. [Abstract]
- SSRN. 2026 Apr 9.
- bioRxiv. 2024 Jul 25.
- Research Square Print. December 6th, 2022.
Biologische Aktivität
Estradiol cypionate (0-30 μM, 72 h) inhibits proliferation of gastric cancer cells (MGC803, SGC7901, and BGC823)[4].
Estradiol cypionate (10-25 μM, 48 h) induces G1/S phase cell cycle arrest, and induces apoptosis by PI3K /Akt/mTOR pathway in gastric cancer cells (MGC803, SGC7901, and BGC823 cells)[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MGC803, SGC7901, and BGC823 cells
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Concentration:10-25 μM
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Incubation Time:48 h
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Result:Increased protein level of cleaved caspase-3 and PARP.
Decreased protein levels of AKT, p-AKT, p-mTOR, p-S6K, and p-4E-BP1.
Estradiol cypionate (1 mg, i.m.) increases occurrence of estrus and pregnancy in cows[3].
Estradiol cypionate (50-100 mg/kg, i.p., every other day) inhibits tumor growth in MGC803 nude mice[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MGC803 nude mice tumor model[4].
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Dosage:50-100 mg/kg
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Administration:i.p., every other day
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Result:Inhibited tumor growth.
Increased Cleaved caspase-3 expression, decreased Ki67, AKT and p-AKT in tumors.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 313-06-4
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Appearance Solid
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Molecular Weight 396.56
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Formel C26H36O3
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Color White to off-white
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SMILES
C[C@@]12[C@@H](OC(CCC3CCCC3)=O)CC[C@@]1([H])[C@]4([H])CCC5=C(C=CC(O)=C5)[C@@]4([H])CC2
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (12)
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Journal Impact Factor
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Most Recent
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J Hematol Oncol
LincK contributes to breast tumorigenesis by promoting proliferation and epithelial-to-mesenchymal transition. [Abstract]2019 Feb 22;12(1):19. PMID: 30795783 -
J Exp Clin Cancer Res
SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane. [Abstract]2020 May 7;39(1):81. PMID: 32381043 -
Biomaterials
Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer. [Abstract]2018 Aug;173:58-70. PMID: 29758547 -
Cell Death Dis
A novel taxane SB-T-101141 triggers a noncanonical ferroptosis to overcome Paclitaxel resistance of breast cancer via iron homeostasis-related KHSRP. [Abstract]2025 May 19;16(1):403. PMID: 40389408 -
Cell Death Dis
2017 May 11;8(5):e2783. PMID: 28492540 -
Phytomedicine
Celastrol as an intestinal FXR inhibitor triggers tripolide-induced intestinal bleeding: Underlying mechanism of gastrointestinal injury induced by Tripterygium wilfordii. [Abstract]2023 Dec:121:155054. PMID: 37738906 -
Int J Mol Sci
2024 Mar 18;25(6):3424. PMID: 38542397 -
Mol Med Rep
2022 Jan;25(1):15. PMID: 34779498 -
Gland Surg
2021 Aug;10(8):2414-2427. PMID: 34527553 -
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Lösungsmittel & Löslichkeit
DMSO : ≥ 30 mg/mL (75.65 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Ethanol : 14.29 mg/mL (36.03 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.67 mg/mL (6.73 mM); Clear solution
This protocol yields a clear solution of ≥ 2.67 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (26.7 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Reinheit & Dokumentation
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Data Sheet (276 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Feng X, et al. NMI inhibits cancer stem cell traits by downregulating hTERT in breast cancer. Cell Death Dis. 2017 May 11;8(5):e2783. [Content Brief]
[2]. Karimian E, et al. Resveratrol treatment delays growth plate fusion and improves bone growth in female rabbits. PLoS One. 2013 Jun 28;8(6):e67859. [Content Brief]
[3]. Sá Filho MF, et al. Impact of hormonal modulation at proestrus on ovarian responses and uterine gene expression of suckled anestrous beef cows. J Anim Sci Biotechnol. 2017 Nov 1;8:79. [Content Brief]
[4]. Qiu X, et al. Estradiol cypionate inhibits proliferation and promotes apoptosis of gastric cancer by regulating AKT ubiquitination. Biomed Pharmacother. 2023 Sep;165:115073. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol / DMSO | 1 mM | 2.5217 mL | 12.6084 mL | 25.2169 mL | 63.0422 mL |
| 5 mM | 0.5043 mL | 2.5217 mL | 5.0434 mL | 12.6084 mL | |
| 10 mM | 0.2522 mL | 1.2608 mL | 2.5217 mL | 6.3042 mL | |
| 15 mM | 0.1681 mL | 0.8406 mL | 1.6811 mL | 4.2028 mL | |
| 20 mM | 0.1261 mL | 0.6304 mL | 1.2608 mL | 3.1521 mL | |
| 25 mM | 0.1009 mL | 0.5043 mL | 1.0087 mL | 2.5217 mL | |
| 30 mM | 0.0841 mL | 0.4203 mL | 0.8406 mL | 2.1014 mL | |
| DMSO | 40 mM | 0.0630 mL | 0.3152 mL | 0.6304 mL | 1.5761 mL |
| 50 mM | 0.0504 mL | 0.2522 mL | 0.5043 mL | 1.2608 mL | |
| 60 mM | 0.0420 mL | 0.2101 mL | 0.4203 mL | 1.0507 mL |
Estradiol cypionate Related Classifications
HY-B1100 Related Classifications
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