Monomethyl lithospermate
Monomethyl lithospermate activates the PI3K/AKT pathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cell apoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS).
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- No. CAS: 933054-33-2
- Fòrmula: C28H24O12
- Peso molecular:552.48
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
In Vitro
Monomethyl lithospermate (5, 10, and 20 μM; 12 h) increases cell viability of SHSY-5Y cells treated by oxygen and glucose deprivation/Reoxygenation (OGD/R)[1].
Monomethyl lithospermate (20 μM; 12 h) alleviates cell damage, mitochondrial membrane potential loss and apoptosis of SHSY-5Y cells after oxygen and glucose deprivation/reoxygenation[1].
Monomethyl lithospermate (5, 10, and 20 μM; 12 h) reduces ROS and intracellular oxidative stress in SHSY-5Y cells[1].
Monomethyl lithospermate (20 μM; 12 h) activates PI3K/AKT in SHSY-5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:SHSY-5Y cells
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Concentration:5, 10, and 20 μM
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Incubation Time:12 hours
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Result:Inhibited the mitochondrial membrane potential (MMOP) collapse and apoptosis of SHSY-5Y cells induced by oxygen and glucose deprivation/Reoxygenation (OGD/R) treatment.
In Vivo
Monomethyl lithospermate can reduce the oxidative stress level and inhibit neuronal apoptosis in MCAO rats[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 933054-33-2
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Peso molecular 552.48
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Fòrmula C28H24O12
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SMILES
O=C(/C=C/C1=C2C(O[C@@H]([C@H]2C(OC)=O)C3=CC(O)=C(O)C=C3)=C(O)C=C1)O[C@H](CC4=CC(O)=C(O)C=C4)C(O)=O
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Synonyms
Lithospermic acid monomethyl ester
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Yang F, et al. Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling. Front Pharmacol. 2022 Oct 13;13:1024439. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Monomethyl lithospermate Related Classifications
HY-N8931 Related Classifications
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