2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. PF-03049423 free base

PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke.

For research use only. We do not sell to patients.

PF-03049423 free base Chemical Structure

PF-03049423 free base Chemical Structure

CAS No. : 954138-07-9

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PF-03049423 free base Related Antibodies

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Description

PF-03049423 (Compound PF-5) free base is a potent and highly selective phosphodiesterase-5A inhibitor with an IC50 of about 0.2 nM for rat and human platelet enzyme. PF-03049423 free base can be used for the research of acute ischaemic stroke[1].

IC50 & Target[1]

PDE5A

 

rat and human platelet enzyme

~0.2 nM (IC50)

In Vivo

PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
Dosage: 0.1, 1, or 10 mg/kg
Administration: Subcutaneous injection, b.i.d. for 7 days
Result: Improved functional recovery at 1 mg/kg and 10 mg/kg.
Clinical Trial
Molecular Weight

468.55

Formula

C24H32N6O4
CAS No.
SMILES

O=C1C(N2CCN(CC2)CCO)=NC3=C(N1CCOCCC)C=C(C4=CC=C(OC)N=C4)N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PF-03049423 free base Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PF-03049423954138-07-9PF03049423PF 03049423Phosphodiesterase (PDE)acute ischaemic strokemiddle cerebral artery occlusionMCA-oInhibitorinhibitorinhibit

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