1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Pramipexole

Pramipexole 

Cat. No.: HY-B0410 Purity: 99.88%
Handling Instructions

Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

For research use only. We do not sell to patients.

Pramipexole Chemical Structure

Pramipexole Chemical Structure

CAS No. : 104632-26-0

Size Price Stock Quantity
500 mg USD 50 In-stock
Estimated Time of Arrival: December 31
1 g   Get quote  
5 g   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Pramipexole

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

IC50 & Target[1]

D2 Receptor

3.9 nM (Ki)

D3 Receptor

0.5 nM (Ki)

D4 Receptor

1.4 nM (Ki)

D2-type receptors

2.2 nM (Ki)

In Vitro

Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].
Pramipexole (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].
Pramipexole improves neurological recovery[5].
Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5]
Dosage: 0.25 mg/kg, 1 mg/kg
Administration: Intraperitoneal injection
Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
Clinical Trial
Molecular Weight

211.33

Formula

C₁₀H₁₇N₃S

CAS No.
SMILES

NC1=NC(CC[[email protected]](NCCC)C2)=C2S1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: 99.88%

  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PramipexoleDopamine ReceptorParkinson'sdiseasePDrestlesslegssyndromeRLSneurologicalrecoveryneuroprotectiontMCAOtransientmiddlecerebralarteryocclusionInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Pramipexole
Cat. No.:
HY-B0410
Quantity:
MCE Japan Authorized Agent: