2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
  4. Pramipexole

Pramipexole 

Cat. No.: HY-B0410 Purity: 99.95%
COA Handling Instructions

Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS).

For research use only. We do not sell to patients.

Pramipexole Chemical Structure

Pramipexole Chemical Structure

CAS No. : 104632-26-0

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pramipexole:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pramipexole

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Pramipexole is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

IC50 & Target[1]

D2 Receptor

3.9 nM (Ki)

D3 Receptor

0.5 nM (Ki)

D4 Receptor

1.3 nM (Ki)

In Vitro

Pramipexole shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1].
Pramipexole (0.01-10 μM; 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3].
Pramipexole attenuates levodopa-induced toxicity in mesencephalic cultures[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Pramipexole (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals[5].
Pramipexole improves neurological recovery[5].
Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats weighing 250-300 g (16-18 weeks old)[5]
Dosage: 0.25 mg/kg, 1 mg/kg
Administration: Intraperitoneal injection
Result: Decreased infarction volume as compared to tMCAO (transient middle cerebral artery occlusion)-only animals.
Clinical Trial
Molecular Weight

211.33

Appearance

Solid

Formula

C10H17N3S
CAS No.
SMILES

NC1=NC(CC[[email protected]](NCCC)C2)=C2S1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (473.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7319 mL 23.6597 mL 47.3194 mL
5 mM 0.9464 mL 4.7319 mL 9.4639 mL
10 mM 0.4732 mL 2.3660 mL 4.7319 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: 10 mg/mL (47.32 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (11.83 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.95%

COA (242 KB) HNMR (127 KB) RP-HPLC (192 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Pramipexole104632-26-0Dopamine ReceptorParkinson'sdiseasePDrestlesslegssyndromeRLSneurologicalrecoveryneuroprotectiontMCAOtransientmiddlecerebralarteryocclusionInhibitorinhibitorinhibit

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