1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Dexpramipexole dihydrochloride

Dexpramipexole dihydrochloride (Synonyms: (R)-Pramipexole (dihydrochloride); R-(+)-Pramipexole (dihydrochloride); KNS-760704 (dihydrochloride))

Cat. No.: HY-17355A Purity: 99.38%
Handling Instructions

Dexpramipexole dihydrochloride, also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist.

For research use only. We do not sell to patients.

Dexpramipexole dihydrochloride Chemical Structure

Dexpramipexole dihydrochloride Chemical Structure

CAS No. : 104632-27-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 360 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of Dexpramipexole dihydrochloride:

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Description

Dexpramipexole dihydrochloride, also known as R-(+)-Pramipexole, is a neuroprotective agent and weak non-ergoline dopamine agonist. IC50 Value: Target: Dopamine Receptor Dexpramipexole has been found to have neuroprotective effects and is being investigated for treatment of amyotrophic lateral sclerosis (ALS). Dexpramipexole reduces mitochondrial reactive oxygen species (ROS) production, inhibits the activation of apoptotic pathways, and increase cell survival in response to a variety of neurotoxins and β-amyloid neurotoxicity. Compared to the S-(-) isomer, Dexpramipexole has much lower dopamine agonist activity.

Molecular Weight

284.25

Formula

C₁₀H₁₉Cl₂N₃S

CAS No.

104632-27-1

SMILES

NC(S1)=NC2=C1C[[email protected]](NCCC)CC2.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 28 mg/mL (98.50 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5180 mL 17.5902 mL 35.1803 mL
5 mM 0.7036 mL 3.5180 mL 7.0361 mL
10 mM 0.3518 mL 1.7590 mL 3.5180 mL
*Please refer to the solubility information to select the appropriate solvent.
References

Purity: 99.38%

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Product Name:
Dexpramipexole dihydrochloride
Cat. No.:
HY-17355A
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