2. Others Metabolic Enzyme/Protease Neuronal Signaling Apoptosis Autophagy Membrane Transporter/Ion Channel Immunology/Inflammation
  3. Ferroptosis Autophagy Reference Standards Sodium Channel Mitophagy NOD-like Receptor (NLR) Glutathione Peroxidase Apoptosis PINK1/Parkin ATP Synthase
  4. Dexpramipexole dihydrochloride (Standard)

Dexpramipexole dihydrochloride (Standard)  (Synonyms: (R)-Pramipexole dihydrochloride (Standard); R-(+)-Pramipexole dihydrochloride (Standard); KNS-760704 dihydrochloride (Standard))

Cat. No.: HY-17355AR Purity: 98%
Handling Instructions Technical Support

Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

For research use only. We do not sell to patients.

Dexpramipexole dihydrochloride (Standard)

Dexpramipexole dihydrochloride (Standard) Chemical Structure

CAS No. : 104632-27-1

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Information

Dexpramipexole ((R)-Pramipexole) dihydrochloride (Standard) is the analytical standard of Dexpramipexole (dihydrochloride). This product is intended for research and analytical applications. Dexpramipexole dihydrochloride is an orally active, blood-brain barrier permeable mitochondrial protective agent. Dexpramipexole dihydrochloride upregulates the expression of Parkin, PINK1, GPX4 and FSP1; binds to mitochondrial F1/Fo-ATP synthase; blocks the Nav1.8 sodium channel; and inhibits the activation of the NLRP3 inflammasome. Dexpramipexole dihydrochloride induces mitophagy, inhibits ferroptosis, pyroptosis, apoptosis, neuroinflammation and eosinophilopoiesis; maintains mitochondrial function and redox homeostasis; reduces reactive oxygen species production; and decreases myocardial infarct size. Dexpramipexole dihydrochloride is applicable to studies on eosinophilic asthma, myocardial ischemia/reperfusion injury, sepsis-associated encephalopathy, analgesia, and more.

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Molecular Weight

284.25

Formula

C10H19Cl2N3S
CAS No.
SMILES

NC(S1)=NC2=C1C[C@H](NCCC)CC2.[H]Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Dexpramipexole dihydrochloride (Standard) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dexpramipexole dihydrochloride (Standard)104632-27-1(R)-Pramipexole dihydrochloride (Standard) R-(+)-Pramipexole dihydrochloride (Standard) KNS-760704 dihydrochloride (Standard)FerroptosisAutophagyReference StandardsSodium ChannelMitophagyNOD-like Receptor (NLR)Glutathione PeroxidaseApoptosisPINK1/ParkinATP SynthaseNa channelsNa+ channelsMitochondrial AutophagyPTEN-induced kinase 1/ParkinInhibitorinhibitorinhibit

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