Cat. No.: HY-B0735A

Fenoldopam mesylate

(Synonyms: Fenoldopam methanesulfonate; SKF-82526 mesylate)

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Fenoldopam mesylate (SKF-82526) is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.

For research use only. We do not sell to patients.

Purity: 99.94%
CAS No.: 67227-57-0
Formula: C₁₇H₂₀ClNO₆S
Molecular Weight:401.86

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Fenoldopam mesylate Chemical Structure

CAS No.: 67227-57-0

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.8974 μM (LSD1)^[2]

All Dopamine Receptor Isoforms :

In Vitro

Fenoldopam is a partial agonist with low efficacy at DA1 receptors linked to cAMP generation in the LLC-PK1 cells^[1].
Fenoldopam (0-300 μM; 48 or 72 h) displays significant antiproliferative activity against RCC cell lines^[2].
Fenoldopam (5 μM and 10 μM; 72 h) induces cell apoptosis in a dose-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

786-O, ACHN, and HK-2 cells
Concentration:

0-300 μM
Incubation Time:

48 or 72 hours
Result:

Inhibited the growth of ACHN cells (IC₅₀=16.55 μM, 48 h; IC₅₀=10.34 μM, 72 h), 786-O cells (IC₅₀=57.89 μM, 48 h; IC₅₀=47.52 μM, 72 h), and HK2 cells (IC₅₀>300 μM, 48h and 72 h).

Apoptosis Analysis^[1]

Cell Line:

ACHN cells
Concentration:

5 μM and 10 μM
Incubation Time:

72 hours
Result:

Increased apoptotic cells from at 2.2% (control) to 47.7% (5 μM, fenoldopam) and 60.8% (10 μM, fenoldopam), respectively.

In Vivo

Fenoldopam mesylate (subcutaneous injection; 100 mg/kg; once daily; 2 d) can induce arteritis in rats detected by magnetic resonance imaging (MRI)^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female Sprague-Dawley rats^[3]
Dosage:

100 mg/kg
Administration:

Subcutaneous injection; 100 mg/kg; once daily; 2 days
Result:

Showed low-intensity areas and a high signal intensity region around the artery, and these findings were considered to be erythrocytes infiltrating the arterial wall and perivascular edema, respectively.
Observed perivascular edema histopathologically.

Chemical Information

CAS No. 67227-57-0
Appearance Solid
Molecular Weight 401.86
Formula C₁₇H₂₀ClNO₆S
Color White to off-white
SMILES

OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
Synonyms

Fenoldopam methanesulfonate; SKF-82526 mesylate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (4)

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Journal Impact Factor

Cell

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. [Abstract]

2021 Feb 18;184(4):943-956.e18. PMID: 33571432
SLAS Discov

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions. [Abstract]

2020 Sep;25(8):895-905. PMID: 32567455
Biochem Biophys Res Commun

Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes. [Abstract]

2022 Jan 15:588:83-89. PMID: 34953210
Biomed Pharmacother

Dopamine receptor agonists ameliorate bleomycin-induced pulmonary fibrosis by repressing fibroblast differentiation and proliferation. [Abstract]

2021 Jul:139:111500. PMID: 33901873

Solvent & Solubility

In Vitro:

DMSO : ≥ 36 mg/mL (89.58 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 10 mg/mL (24.88 mM; Need ultrasonic)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4884 mL

12.4421 mL

24.8843 mL

5 mM

0.4977 mL

2.4884 mL

4.9769 mL

10 mM

0.2488 mL

1.2442 mL

2.4884 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. [Content Brief]

[2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. [Content Brief]

[3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.4884 mL	12.4421 mL	24.8843 mL	62.2107 mL
	5 mM	0.4977 mL	2.4884 mL	4.9769 mL	12.4421 mL
	10 mM	0.2488 mL	1.2442 mL	2.4884 mL	6.2211 mL
	15 mM	0.1659 mL	0.8295 mL	1.6590 mL	4.1474 mL
	20 mM	0.1244 mL	0.6221 mL	1.2442 mL	3.1105 mL
DMSO	25 mM	0.0995 mL	0.4977 mL	0.9954 mL	2.4884 mL
	30 mM	0.0829 mL	0.4147 mL	0.8295 mL	2.0737 mL
	40 mM	0.0622 mL	0.3111 mL	0.6221 mL	1.5553 mL
	50 mM	0.0498 mL	0.2488 mL	0.4977 mL	1.2442 mL
	60 mM	0.0415 mL	0.2074 mL	0.4147 mL	1.0368 mL
	80 mM	0.0311 mL	0.1555 mL	0.3111 mL	0.7776 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Fenoldopam mesylate

4 Cited Publications

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Fenoldopam mesylate

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Publications Citing Use of MedChemExpress (MCE) Fenoldopam mesylate

All Dopamine Receptor Isoforms

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Fenoldopam mesylate Related Classifications

HY-B0735A Related Classifications