1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Fenoldopam mesylate

Fenoldopam mesylate (Synonyms: Fenoldopam methanesulfonate; SKF-82526 mesylate)

Cat. No.: HY-B0735A Purity: 99.86%
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Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist.

For research use only. We do not sell to patients.

Fenoldopam mesylate Chemical Structure

Fenoldopam mesylate Chemical Structure

CAS No. : 67227-57-0

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Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
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ready for reconstitution
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Estimated Time of Arrival: December 31
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10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 170 In-stock
Estimated Time of Arrival: December 31
100 mg USD 260 In-stock
Estimated Time of Arrival: December 31
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Based on 3 publication(s) in Google Scholar

Other Forms of Fenoldopam mesylate:

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Description

Fenoldopam(SKF 82526) mesylate is a drug and synthetic benzazepine derivative which acts as a selective D1 receptor partial agonist. Target: D1 Receptor Fenoldopam is a selective dopamine-1 (DA1) agonist with natriuretic/diuretic properties. Fenoldopam stimulated cAMP accumulation in LLC-PK1 cells in a dose-dependent manner, an effect which could be blocked by the DA1-selective antagonist Sch 23390. Although fenoldopam was more potent than DA (EC50 55.5 +/- 7.75 nM vs. 1.65 +/- 0.64 microM) in stimulating cAMP accumulation in LLC-PK1 cells, the maximum stimulation obtained by fenoldopam was only 37% of the maximum stimulation obtained by DA(Emax 13.0 +/- 2.95 pmol/mg of protein vs. 35.6 +/- 10.19 pmol/mg of protein) [1]. Fenoldopam is a selective dopamine1 (DA1) receptor agonist. Most of the DA1 receptor agonist activity of fenoldopam resides in the R-enantiomer, which also shows weaker alpha 2-adrenoceptor antagonist activity Fenoldopam produces vasodilation in vascular beds that are rich in vascular DA1 receptors [2].

Clinical Trial
Molecular Weight

401.86

Formula

C₁₇H₂₀ClNO₆S

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 36 mg/mL (89.58 mM)

H2O : 10 mg/mL (24.88 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

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Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4884 mL 12.4421 mL 24.8843 mL
5 mM 0.4977 mL 2.4884 mL 4.9769 mL
10 mM 0.2488 mL 1.2442 mL 2.4884 mL
*Please refer to the solubility information to select the appropriate solvent.
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Fenoldopam mesylate
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HY-B0735A
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