2. GPCR/G Protein
    Neuronal Signaling
  3. Dopamine Receptor
    Adrenergic Receptor
    5-HT Receptor
  4. Rotigotine

Rotigotine  (Synonyms: N-0437; N-0923)

Cat. No.: HY-75502 Purity: 99.87%
COA Handling Instructions

Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research.

For research use only. We do not sell to patients.

Rotigotine Chemical Structure

Rotigotine Chemical Structure

CAS No. : 99755-59-6

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10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
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ready for reconstitution
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50 mg USD 336 In-stock
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100 mg USD 480 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Rotigotine:

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Rotigotine

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

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  • Customer Review

Description

Rotigotine is a potent dopamine receptor agonist with Ki values of 0.71 nM, 4-15 nM, and 83 nM for the dopamine D3 receptor and D2, D5, D4 receptors and dopamine D1 receptor. Rotigotine a partial agonist of the 5-HT1A receptor, and an antagonist of the α2B-adrenergic receptor. Rotigotine can be used for parkinson's disease (PD) research[1][2][3][4].

IC50 & Target[1][4]

D3 Receptor

0.71 nM (Ki)

D2 Receptor

4-15 nM (Ki)

D5 Receptor

4-15 nM (Ki)

D4 Receptor

4-15 nM (Ki)

D1 Receptor

83 nM (Ki)

5-HT1A Receptor

30 nM (Ki)

5-HT7 Receptor

86 nM (Ki)

In Vitro

Rotigotine (0.01-10 µM) slightly protects dopaminergic neurons against MPP+ toxicity dopamine, protects dopaminergic neurons against rotenone-induced cell death and significantly inhibits ROS production by rotenone[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Rotigotine (0.1-5 mg/kg; i.h.; for 14 days; male Sprague–Dawley rats) has antidepressant effect[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats[3]
Dosage: 0.1, 0.5, 1, and 5 mg/kg
Administration: Subcutaneous injection; for 14 days.
Result: Had antidepressant effect at a dose of 1 mg/kg or less. expression.
Clinical Trial
Molecular Weight

315.47

Appearance

Solid

Formula

C19H25NOS
CAS No.
SMILES

CCCN(CCC1=CC=CS1)[[email protected]]2CCC3=C(C=CC=C3O)C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 50 mg/mL (158.49 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1699 mL 15.8494 mL 31.6987 mL
5 mM 0.6340 mL 3.1699 mL 6.3397 mL
10 mM 0.3170 mL 1.5849 mL 3.1699 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.92 mM); Suspended solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 99.98% ee.: 100.00%

COA (247 KB) HNMR (196 KB) RP-HPLC (361 KB) LCMS (495 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

Rotigotine99755-59-6N-0437 N-0923N0437N 0437N0923N 0923N-0923Dopamine ReceptorAdrenergic Receptor5-HT ReceptorBeta ReceptorSerotonin Receptor5-hydroxytryptamine Receptordopaminereceptor5-HT1Aα2B-adrenergicInhibitorinhibitorinhibit

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