2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF 81297 hydrobromide

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist.

For research use only. We do not sell to patients.

SKF 81297 hydrobromide Chemical Structure

SKF 81297 hydrobromide Chemical Structure

CAS No. : 67287-39-2

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5 mg USD 220 In-stock
10 mg USD 350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of SKF 81297 hydrobromide:

SKF 81297 hydrobromide Related Antibodies

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  • Biological Activity

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Description

SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist[1].

IC50 & Target

D1 Receptor

 

In Vivo

SKF 81297 hydrobromide (0.05-0.3 mg/kg, i.m., once) stimulates motor behaviour of MPTP-lesioned monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four male rhesus monkeys (Macaca mulatta, 7.0-11.3 kg)[1]
Dosage: 0.05-0.3 mg/kg
Administration: Injected intramuscularly (i.m.), once
Result: Significantly increased rotational behaviour and right-sided hand use in unilateral MPTP-lesioned rhesus monkeys.
Molecular Weight

370.67

Formula

C16H17BrClNO2
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC2=C(C(Cl)=C1O)CCNCC2C3=CC=CC=C3.Br
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 20 mg/mL (53.96 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : ≥ 20 mg/mL (53.96 mM)

Ethanol : ≥ 2 mg/mL (5.40 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6978 mL 13.4891 mL 26.9782 mL
5 mM 0.5396 mL 2.6978 mL 5.3956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.6978 mL 13.4891 mL 26.9782 mL 67.4454 mL
5 mM 0.5396 mL 2.6978 mL 5.3956 mL 13.4891 mL
DMSO / DMF 10 mM 0.2698 mL 1.3489 mL 2.6978 mL 6.7445 mL
15 mM 0.1799 mL 0.8993 mL 1.7985 mL 4.4964 mL
20 mM 0.1349 mL 0.6745 mL 1.3489 mL 3.3723 mL
25 mM 0.1079 mL 0.5396 mL 1.0791 mL 2.6978 mL
30 mM 0.0899 mL 0.4496 mL 0.8993 mL 2.2482 mL
40 mM 0.0674 mL 0.3372 mL 0.6745 mL 1.6861 mL
50 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3489 mL
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SKF 81297 hydrobromide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 8129767287-39-2SKF81297SKF-81297Dopamine ReceptorInhibitorinhibitorinhibit

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