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Cat. No.: HY-110021

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Fenoldopam hydrochloride

(Synonyms: SKF 82526 hydrochloride)

4 Cited Publications

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Based on 4 publication(s) in Google Scholar

Fenoldopam (SKF 82526) hydrochloride is a D₁ receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC₅₀=0.8974 μM). Fenoldopam hydrochloride shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis.

For research use only. We do not sell to patients.

CAS No.: 181217-39-0
Formula: C₁₆H₁₇Cl₂NO₃
Molecular Weight:342.22

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (275 KB)

Fenoldopam hydrochloride Chemical Structure

CAS No.: 181217-39-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 0.8974 μM (LSD1)^[2]

All Dopamine Receptor Isoforms :

All Histone Demethylase Isoforms :

Chemical Information

CAS No. 181217-39-0
Molecular Weight 342.22
Formula C₁₆H₁₇Cl₂NO₃
SMILES

ClC1=C(CCNCC2C3=CC=C(C=C3)O)C2=CC(O)=C1O.Cl
Synonyms

SKF 82526 hydrochloride
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Cell

Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. [Abstract]

2021 Feb 18;184(4):943-956.e18. PMID: 33571432
SLAS Discov

A Novel Flow Cytometric Assay to Identify Inhibitors of RBPJ-DNA Interactions. [Abstract]

2020 Sep;25(8):895-905. PMID: 32567455
Biochem Biophys Res Commun

Dopamine receptor D1 signaling stimulates lipolysis and browning of white adipocytes. [Abstract]

2022 Jan 15:588:83-89. PMID: 34953210
Biomed Pharmacother

Dopamine receptor agonists ameliorate bleomycin-induced pulmonary fibrosis by repressing fibroblast differentiation and proliferation. [Abstract]

2021 Jul:139:111500. PMID: 33901873

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (275 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. [Content Brief]

[2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. [Content Brief]

[3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Fenoldopam hydrochloride

4 Cited Publications

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Publications (4)
Purity & Documentation
References

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Fenoldopam hydrochloride

Publications Citing Use of MedChemExpress (MCE) Fenoldopam hydrochloride

All Dopamine Receptor Isoforms

All Histone Demethylase Isoforms

Biological Activity

Chemical Information

Publications (4)

Purity & Documentation

References

Calculators

Help & FAQs

Fenoldopam hydrochloride Related Classifications

HY-110021 Related Classifications