67227-57-0
67227-57-0
Chemical Structure
Fenoldopam mesylate
Synonym(s): Fenoldopam methanesulfonate; SKF-82526 mesylate
- CAS No.: 67227-57-0
- Formula:C17H20ClNO6S
- Molecular Weight:401.86
IUPAC Name: 6-chloro-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine-7,8-diol methanesulfonate
InChIKey: CVKUMNRCIJMVAR-UHFFFAOYSA-N
SMILES: OC1=C(O)C=C2C(C3=CC=C(O)C=C3)CNCCC2=C1Cl.CS(=O)(O)=O
Biological Activity: Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Fenoldopam mesylate | 99.94% | Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Fenoldopam mesylate (Standard) | ≥98% | Fenoldopam (mesylate) (Standard) is the analytical standard of Fenoldopam (mesylate). This product is intended for research and analytical applications. Fenoldopam mesylate (SKF-82526) is a D1 receptor agonist and a novel lysine-specific demethylase 1 (LSD1) inhibitor (IC50=0.8974 μM). Fenoldopam mesylate shows anti-hypertensive effects, anti-cancer cell proliferation activity and can induce cells apoptosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. A Grenader, et al. Fenoldopam is a partial agonist at dopamine-1 (DA1) receptors in LLC-PK1 cells. J Pharmacol Exp Ther. 1991 Jul 1;258(1):193-8. [Content Brief]
- [2]. Yan Zheng, et al. Identification of fenoldopam as a novel LSD1 inhibitor to abrogate the proliferation of renal cell carcinoma using drug repurposing strategy. Bioorg Chem. 2021 Mar;108:104561. [Content Brief]
- [3]. Yuta Fujii, et al. Detection of fenoldopam-induced arteritis in rats using ex vivo / in vivo MRI. Toxicology Reports, Volume 9, 2022, Pages 1595-1602.
