1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. Dopamine Receptor
    5-HT Receptor
    Potassium Channel
  3. SCH-23390 hydrochloride

SCH-23390 hydrochloride (Synonyms: R-(+)-SCH-23390 hydrochloride)

Cat. No.: HY-19545A Purity: 99.31%
Handling Instructions

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.

For research use only. We do not sell to patients.

SCH-23390 hydrochloride Chemical Structure

SCH-23390 hydrochloride Chemical Structure

CAS No. : 125941-87-9

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10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
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10 mg USD 114 In-stock
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25 mg USD 252 In-stock
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50 mg USD 468 In-stock
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100 mg USD 852 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of SCH-23390 hydrochloride:

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Description

SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM[1][2][3].

IC50 & Target[1][2][3]

D1 Receptor

0.2 nM (Ki)

D5 Receptor

0.3 nM (Ki)

5-HT2C Receptor

9.3 nM (Ki)

GIRK

268 nM (IC50)

In Vitro

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].

In Vivo

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants: pilocarpine and soman. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D1 receptors in rodents, nonhuman primates, and humans[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].

Molecular Weight

324.24

Formula

C₁₇H₁₉Cl₂NO

CAS No.

125941-87-9

SMILES

OC1=C(Cl)C=C2CCN(C)C[[email protected]](C3=CC=CC=C3)C2=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (98.69 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0841 mL 15.4207 mL 30.8414 mL
5 mM 0.6168 mL 3.0841 mL 6.1683 mL
10 mM 0.3084 mL 1.5421 mL 3.0841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[5]

Rats: All rats receive acclimatization saline injections the two afternoons 1 prior to 2 their test day. At the end of the Training phase, rats (n=15 or 16 rats/group) are assigned to one 3 of three conditions (0, 1, or 10 μg/kg IP injections of SCH 23390). The day following the Training phase, rats are tested in the operant 6 conditioning chambers for saccharin cue-reactivity (saccharin seeking)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.31%

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Keywords:

SCH-23390R-(+)-SCH-23390SCH23390SCH 23390Dopamine Receptor5-HT ReceptorPotassium ChannelSerotonin Receptor5-hydroxytryptamine ReceptorKcsADA1-likeductusconstrictionepileptiformneurologicalenantioselective5‐HT25‐HT1CD5-receptorGIRKInhibitorinhibitorinhibit

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SCH-23390 hydrochloride
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