1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. SCH 23390 hydrochloride

SCH 23390 hydrochloride (Synonyms: R-(+)-SCH23390 hydrochloride)

Cat. No.: HY-19545A Purity: 99.31%
Handling Instructions

SCH 23390 hydrochloride is a potent dopamine receptor D1 antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5.

For research use only. We do not sell to patients.

SCH 23390 hydrochloride Chemical Structure

SCH 23390 hydrochloride Chemical Structure

CAS No. : 125941-87-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
10 mg USD 114 In-stock
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25 mg USD 252 In-stock
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50 mg USD 468 In-stock
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100 mg USD 852 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

SCH 23390 hydrochloride is a potent dopamine receptor D1 antagonist with Ki values of 0.2 and 0.3 nM for the D1 and D5.

IC50 & Target

Ki: 0.2 nM (D1), 0.3 nM (D5)[1]

In Vitro

The commercially available hydrochloride salt has a molecular weight of 324.25 and is a white solid soluble in water (8 mg/mL), DMSO (3 mg/mL), or ethanol (2 mg/mL)[1]. SCH 23390 also shows high affinity (Ki=9.3 nM) at h5-HT2C sites[2]. SCH23390 blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells (IC50=268 nM)[3].

In Vivo

SCH 23390 has been a major tool in gaining a better understanding of the role of the dopamine system. SCH 23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1]. The repeated administration of SCH 23390 (0.05 mg/kg s.c., thrice daily for 21 days) enhances the steady-state density of dopamine D1 receptors in the striatum (+30%) and substantia nigra (+24%). This treatment also increases the production rates of dopamine D1 receptors in the striatum (+44%) and substantia nigra (+54%)[4]. Systemic SCH 23390 reduces saccharin seeking evidenced by a significant reduction in active lever responding and a significant reduction in the number of active lever-contingent deliveries of the tone + light cue following pretreatment with 10 μg/kg SCH 23390[5].

Molecular Weight

324.24

Formula

C₁₇H₁₉Cl₂NO

CAS No.

125941-87-9

SMILES

OC1=C(Cl)C=C2CCN(C)C[[email protected]](C3=CC=CC=C3)C2=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 32 mg/mL (98.69 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0841 mL 15.4207 mL 30.8414 mL
5 mM 0.6168 mL 3.0841 mL 6.1683 mL
10 mM 0.3084 mL 1.5421 mL 3.0841 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Animal Administration
[5]

Rats: All rats receive acclimatization saline injections the two afternoons 1 prior to 2 their test day. At the end of the Training phase, rats (n=15 or 16 rats/group) are assigned to one 3 of three conditions (0, 1, or 10 μg/kg IP injections of SCH 23390). The day following the Training phase, rats are tested in the operant 6 conditioning chambers for saccharin cue-reactivity (saccharin seeking)[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.31%

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Keywords:

SCH 23390R-(+)-SCH23390SCH23390SCH-23390Dopamine ReceptorInhibitorinhibitorinhibit

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SCH 23390 hydrochloride
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HY-19545A
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