SCH-23390 hydrochloride (Synonyms: R-(+)-SCH-23390 hydrochloride)

Name: SCH-23390 hydrochloride
Brand: MedChemExpress
SKU: HY-19545A
Rating: 5.0 (31 reviews)

Cat. No.: HY-19545A Purity: 99.83% ee.: 100.00%: Data Sheet
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SCH-23390 hydrochloride (R-(+)-SCH-23390 hydrochloride) is a potent and selective dopamine D₁-like receptor antagonist with K_is of 0.2 nM and 0.3 nM for the D₁ and D₅ receptor, respectively. SCH-23390 hydrochloride is a potent and high efficacy human 5-HT_2C receptor agonist with a K_i of 9.3 nM. SCH-23390 hydrochloride also binds with high affinity to the 5-HT₂ and 5-HT_1C receptors. SCH-23390 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC₅₀ of 268 nM.

For research use only. We do not sell to patients.

CAS No. : 125941-87-9

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 31 publication(s) in Google Scholar

Other Forms of SCH-23390 hydrochloride:

31 Publications Citing Use of MCE SCH-23390 hydrochloride

Bio/Physico-chemical Assay

In Vivo Efficacy Study

: SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.

: SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).

: SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.

: SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]; GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).

: SCH-23390 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]; SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.

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5-HT Receptor 5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor

Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target^[1]^[2]^[3]

5-HT_1C Receptor

5-HT_2C Receptor

D₁ Receptor

0.2 nM (Ki)

D₅ Receptor

0.3 nM (Ki)

5-HT_2C Receptor

9.3 nM (Ki)

GIRK

268 nM (IC₅₀)

In Vitro

SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SCH-23390 can abolish generalized seizures evoked by the chemoconvulsants. SCH-23390 has also been used in studies of other neurological disorders in which the dopamine system has been implicated, such as psychosis and Parkinson's disease. Apart from the study of neurological disorders, SCH-23390 has been extensively used as a tool in the topographical determination of brain D₁ receptors in rodents, nonhuman primates, and humans^[1].
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat^[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O₂ conditions^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

324.24

Formula

C₁₇H₁₉Cl₂NO

CAS No.

125941-87-9

Appearance

Solid

Color

White to light yellow

SMILES

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (308.41 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 100 mg/mL (308.41 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0841 mL	15.4207 mL	30.8414 mL
5 mM	0.6168 mL	3.0841 mL	6.1683 mL
10 mM	0.3084 mL	1.5421 mL	3.0841 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.83% ee.: 100.00%

Select Batch:

Data Sheet (286 KB) SDS (252 KB)

COA (257 KB) HNMR (251 KB) RP-HPLC (256 KB) NP-HPLC (329 KB) LCMS (108 KB) Elemental Analysis Report (115 KB)

Handling Instructions (2659 KB)

References

[1]. Bourne JA, et al . SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 2001 Winter;7(4):399-414. [Content Brief]

[2]. Millan MJ, et al. The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl). 2001 Jun;156(1):58-62. [Content Brief]

[3]. Kuzhikandathil EV, et al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupledinwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26. [Content Brief]

[4]. Wang YH, et al. Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Content Brief]

[5]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. [Content Brief]

Animal Administration
^[5]

Rats: All rats receive acclimatization saline injections the two afternoons 1 prior to 2 their test day. At the end of the Training phase, rats (n=15 or 16 rats/group) are assigned to one 3 of three conditions (0, 1, or 10 μg/kg IP injections of SCH 23390). The day following the Training phase, rats are tested in the operant 6 conditioning chambers for saccharin cue-reactivity (saccharin seeking)^[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

[1]. Bourne JA, et al . SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 2001 Winter;7(4):399-414. [Content Brief]

[2]. Millan MJ, et al. The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl). 2001 Jun;156(1):58-62. [Content Brief]

[3]. Kuzhikandathil EV, et al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupledinwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26. [Content Brief]

[4]. Wang YH, et al. Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Content Brief]

[5]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.0841 mL	15.4207 mL	30.8414 mL	77.1034 mL
	5 mM	0.6168 mL	3.0841 mL	6.1683 mL	15.4207 mL
	10 mM	0.3084 mL	1.5421 mL	3.0841 mL	7.7103 mL
	15 mM	0.2056 mL	1.0280 mL	2.0561 mL	5.1402 mL
	20 mM	0.1542 mL	0.7710 mL	1.5421 mL	3.8552 mL
	25 mM	0.1234 mL	0.6168 mL	1.2337 mL	3.0841 mL
	30 mM	0.1028 mL	0.5140 mL	1.0280 mL	2.5701 mL
	40 mM	0.0771 mL	0.3855 mL	0.7710 mL	1.9276 mL
	50 mM	0.0617 mL	0.3084 mL	0.6168 mL	1.5421 mL
	60 mM	0.0514 mL	0.2570 mL	0.5140 mL	1.2851 mL
	80 mM	0.0386 mL	0.1928 mL	0.3855 mL	0.9638 mL
	100 mM	0.0308 mL	0.1542 mL	0.3084 mL	0.7710 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

SCH-23390 hydrochloride Related Classifications

Neurological Disease

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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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SCH-23390 hydrochloride (Synonyms: R-(+)-SCH-23390 hydrochloride)

Customer Review

Other Forms of SCH-23390 hydrochloride:

SCH-23390 hydrochloride Related Antibodies

31 Publications Citing Use of MCE SCH-23390 hydrochloride

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•Related Screening Libraries:

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•Related Proteins:

View All Dopamine Receptor Isoform Specific Products:

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Biological Activity

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Purity & Documentation

References

Customer Review

SCH-23390 hydrochloride Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

SCH-23390 hydrochloride Related Classifications

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