SCH-23390 (Synonyms: R-(+)-SCH-23390)

Cat. No.: HY-19545: Data Sheet Handling Instructions
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SCH-23390 is a dopamine D1-like receptor antagonist (with K_i values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system.

For research use only. We do not sell to patients.

CAS No. : 87075-17-0

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Other In-stock Forms of SCH-23390:

SCH-23390 hydrochloride

Other Forms of SCH-23390:

31 Publications Citing Use of MCE SCH-23390

Bio/Physico-chemical Assay

In Vivo Efficacy Study

: SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.

: SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).

: SCH-23390 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]; Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.

: SCH-23390 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]; GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).

: SCH-23390 purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]; SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.

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Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
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Description

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	1.4 nM Compound: R(+)-SCH-23390	Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs Displacement of [3H]SCH23390 from human recombinant dopamine D1 receptor expressed in CHO cells after 2 hrs	[PMID: 23403082]
HEK293	IC₅₀	2.52 nM Compound: 1, SCH23390	Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells	[PMID: 22748706]

Molecular Weight

287.78

Formula

C₁₇H₁₈ClNO

CAS No.

87075-17-0

SMILES

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dakota B Zinani, et al. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Sci Rep. 2023 Sep 4;13(1):14566. [Content Brief]

[2]. J A Bourne, et al. SCH 23390: the first selective dopamine D1-like receptor antagonist. [Content Brief]

SCH-23390 Related Classifications

Neurological Disease

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCH-2339087075-17-0R-(+)-SCH-23390SCH23390SCH 23390Dopamine Receptorcocaineratlever pressing behaviorInhibitorinhibitorinhibit

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