SCH-23390 maleate
Based on 34 publication(s) in Google Scholar
SCH-23390 maleate (R-(+)-SCH-23390 maleate) is a potent and selective dopamine D1-like receptor antagonist with Kis of 0.2 nM and 0.3 nM for the D1 and D5 receptor, respectively. SCH-23390 maleate is a potent and high efficacy human 5-HT2C receptor agonist with a Ki of 9.3 nM. SCH-23390 maleate also binds with high affinity to the 5-HT2 and 5-HT1C receptors. SCH-23390 maleate inhibits G protein-coupled inwardly rectifying potassium (GIRK) channels with an IC50 of 268 nM.
For research use only. We do not sell to patients.
- CAS No.: 87134-87-0
- Formula: C21H22ClNO5
- Molecular Weight:403.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Publications Citing Use of MedChemExpress (MCE) SCH-23390 maleate
More- Nat Commun. 2026 Jun 16. [Abstract]
- Nat Commun. 2024 Jun 10;15(1):4947. [Abstract]
- Nat Commun. 2024 May 1;15(1):3685. [Abstract]
- Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
- Microbiome. 2020 Aug 20;8(1):120. [Abstract]
- Adv Sci (Weinh). 2025 Sep;12(33):e02276. [Abstract]
- J Neuroinflammation. 2026 Apr 23. [Abstract]
- J Hazard Mater. 2025 Sep 15:496:139466. [Abstract]
- Acta Pharmacol Sin. 2026 Apr 24. [Abstract]
- Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
- Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Abstract]
- Int J Biol Macromol. 2023 Aug 30:247:125703. [Abstract]
- Cell Rep. 2024 Sep 10;43(9):114717. [Abstract]
- Neuropsychopharmacology. 2024 Aug;49(9):1468-1480. [Abstract]
- Biochem Pharmacol. 2026 Feb:244:117576. [Abstract]
- Food Biosci. 2025 Oct.
- Eur J Pharmacol. 2024 Oct 15:981:176866. [Abstract]
- Int Immunopharmacol. 2020 Nov:88:106963. [Abstract]
- Neurochem Int. 2023 Feb:163:105479. [Abstract]
- J Psychiatry Neurosci. 2024 Feb 1;49(1):E23-E34. [Abstract]
- Brain Res Bull. 2021 Oct:175:136-149. [Abstract]
- Aquaculture. 2025 Apr 15.
- J Neurosci. 2025 Sep 3;45(36):e0382252025. [Abstract]
- Insect Biochem Mol Biol. 2025 May:180:104312. [Abstract]
- J Neurosci. 2024 Aug 21;44(34):e0740242024. [Abstract]
- Mol Brain. 2025 Jul 16;18(1):63. [Abstract]
- Viruses. 2021 Aug 3;13(8):1533. [Abstract]
- Psychopharmacology (Berl). 2022 Mar;239(3):951-964. [Abstract]
- Biochem Biophys Res Commun. 2022 Nov 12:629:183-188. [Abstract]
- Biochem Biophys Res Commun. 2022 Jan 15:588:83-89. [Abstract]
- Med Sci Monit. 2021 Oct 18;27:e933278. [Abstract]
- Neurosci Lett. 2021 Aug 24:760:136102. [Abstract]
- Behav Pharmacol. 2024 Jun 1;35(4):193-200. [Abstract]
- bioRxiv. 2024 Dec 23:2024.12.22.629999. [Abstract]
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All Dopamine Receptor Isoforms
MoreAll 5-HT Receptor Isoforms
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Biological Activity
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5-HT1C Receptor |
5-HT2C Receptor |
D1 Receptor 0.2 nM (Ki) |
D5 Receptor 0.3 nM (Ki) |
5-HT2C Receptor 9.3 nM (Ki) |
GIRK 268 nM (IC50) |
SCH-23390 (1 μM) treatment reverses the inhibitory effects of Isosibiricin on NLRP3 expression and the cleavages of caspase-1 and IL-1β in the LPS-induced BV-2 cells. SCH-23390 could reverse the Isosibiricin-mediated inhibition of the NLRP3/caspase-1 inflammasome pathway[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
SCH-23390 is a very short-acting compound with an elimination half-life of around 25 min following administration of 0.3 mg/kg i.p. in the rat[1].
SCH-23390 augments dopamine-induced ductus constriction in CD-1 mouse vessels under newborn O2 conditions[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 87134-87-0
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Molecular Weight 403.86
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Formula C21H22ClNO5
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SMILES
OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1.O=C(O)/C=C\C(O)=O
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Synonyms
R-(+)-SCH-23390 maleate
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (34)
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Journal Impact Factor
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Most Recent
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Nat Commun
Targeting dopamine transporter for treating social transmission of depression-like behaviors in male mice. [Abstract]2026 Jun 16. PMID: 42303982 -
Nat Commun
Midbrain glutamatergic circuit mechanism of resilience to socially transferred allodynia in male mice. [Abstract]2024 Jun 10;15(1):4947. PMID: 38858350 -
Nat Commun
Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. [Abstract]2024 May 1;15(1):3685. PMID: 38693116 -
Nat Commun
Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection. [Abstract]2020 Feb 18;11(1):941. PMID: 32071304
SCH-23390 maleate purchased from MedChemExpress. Usage Cited in: Nat Commun. 2020 Feb 18;11(1):941. [Abstract]
GSH levels in astrocytes treated with 10 μM cabergoline for 12 h after pretreatment with SCH23390 (10 μM) or sulpiride (10 μM).
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Microbiome
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice. [Abstract]2020 Aug 20;8(1):120. PMID: 32819434
SCH-23390 maleate purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]
SCH23390 (0.05, 0.1, 0.2 μg/mouse) induced decreased social behavior in C57BL/6J mice.
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Adv Sci (Weinh)
Dopamine D1 Receptor Contributes to Glucocorticoid-Associated Osteonecrosis of Femoral Head Protection Through the ATF3/CHOP Axis to Inhibit Osteoblastic Apoptosis. [Abstract]2025 Sep;12(33):e02276. PMID: 40583147 -
J Neuroinflammation
Dopamine signaling governs macrophage-mediated acute lung injury through JAML/IL-10-coupled mitochondrial regulation. [Abstract]2026 Apr 23. PMID: 42026623 -
J Hazard Mater
Early-life microplastic exposure elicits ADHD-like behaviors by disrupting dopaminergic neurodevelopment in zebrafish. [Abstract]2025 Sep 15:496:139466. PMID: 40779870 -
Acta Pharmacol Sin
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model. [Abstract]2026 Apr 24. PMID: 42032133 -
Acta Pharmacol Sin
The classical D1 dopamine receptor antagonist SCH23390 is a functional sigma-1 receptor allosteric modulator. [Abstract]2024 Aug;45(8):1582-1590. PMID: 38605179
SCH-23390 maleate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
SCH23390 (10 μM, 2 h) decreased the association between Sig1R and BiP by Co-IP.
SCH-23390 maleate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
We detected increased translocation of Sig1R to plasma membrane in SH-SY5Y cells treated with SCH23390 (10 μM, 2 h).
SCH-23390 maleate purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2024 Aug;45(8):1582-1590. [Abstract]
Primary neurons from WT and Sig1R KO mice were pre-treated with SCH23390 (10 μM) or SKF10047 (0.5 or 5 μM) for 30 min prior to and during treatment with MPP+ (800 μM). After incubation for 24 h, cells were fixed and subjected to immunostaining with an anti-MAP2 antibody (1:2000) as described, followed by double-staining with TUNEL (red) and Hoechst (blue). SCH23390 synergistically promotes the neuroprotective effect of the Sig1R agonist, SKF10047.
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Acta Pharmacol Sin
Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. [Abstract]2020 Feb;41(2):173-180. PMID: 31506572 -
Int J Biol Macromol
Structural and expression analysis of the dopamine receptors reveals their crucial roles in regulating the insulin signaling pathway in oysters. [Abstract]2023 Aug 30:247:125703. PMID: 37414315 -
Cell Rep
Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania. [Abstract]2024 Sep 10;43(9):114717. PMID: 39264811 -
Neuropsychopharmacology
2024 Aug;49(9):1468-1480. PMID: 38734818 -
Biochem Pharmacol
2026 Feb:244:117576. PMID: 41319924 -
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Eur J Pharmacol
The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference. [Abstract]2024 Oct 15:981:176866. PMID: 39089461 -
Int Immunopharmacol
Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice. [Abstract]2020 Nov:88:106963. PMID: 33182028 -
Neurochem Int
Anti-inflammatory effects of dopamine on microglia and a D1 receptor agonist ameliorates neuroinflammation of the brain in a rat delirium model. [Abstract]2023 Feb:163:105479. PMID: 36608872 -
J Psychiatry Neurosci
Reviving: restoring depression-like behaviour through glial cell-derived neurotrophic factor treatment in the medial prefrontal cortex. [Abstract]2024 Feb 1;49(1):E23-E34. PMID: 38302136 -
Brain Res Bull
DRD1 agonist A-68930 improves mitochondrial dysfunction and cognitive deficits in a streptozotocin-induced mouse model. [Abstract]2021 Oct:175:136-149. PMID: 34284074 -
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J Neurosci
Potentiation of Nigra-Striatal Dopaminergic Projection Underpins Core Autism-Like Behaviors in Valproate-Exposed Mice. [Abstract]2025 Sep 3;45(36):e0382252025. PMID: 40769723 -
Insect Biochem Mol Biol
Molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis. [Abstract]2025 May:180:104312. PMID: 40245998 -
J Neurosci
Acute Ongoing Nociception Delays Recovery of Consciousness from Sevoflurane Anesthesia via a Midbrain Circuit. [Abstract]2024 Aug 21;44(34):e0740242024. PMID: 39019613 -
Mol Brain
The regulation of rhythmic locomotion by motor cortical and dopaminergic inputs in the mouse striatum. [Abstract]2025 Jul 16;18(1):63. PMID: 40671088 -
Viruses
Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3. [Abstract]2021 Aug 3;13(8):1533. PMID: 34452398 -
Psychopharmacology (Berl)
Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway. [Abstract]2022 Mar;239(3):951-964. PMID: 35190859 -
Biochem Biophys Res Commun
Expression changes of c-Fos and D1R/p-ERK1/2 signal pathways in nucleus accumbens of rats after ketamine abuse. [Abstract]2022 Nov 12:629:183-188. PMID: 36152451 -
Biochem Biophys Res Commun
2022 Jan 15:588:83-89. PMID: 34953210 -
Med Sci Monit
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons. [Abstract]2021 Oct 18;27:e933278. PMID: 34657931 -
Neurosci Lett
D1R/PP2A/p-CaMKIIα signaling in the caudate putamen is involved in acute methamphetamine-induced hyperlocomotion. [Abstract]2021 Aug 24:760:136102. PMID: 34237414 -
Behav Pharmacol
SKF82958, a dopamine D1 receptor agonist, disrupts prepulse inhibition in the medial prefrontal cortex and nucleus accumbens in C57BL/6J mice. [Abstract]2024 Jun 1;35(4):193-200. PMID: 38567425 -
bioRxiv
In vivo multiplex imaging of dynamic neurochemical networks with designed far-red dopamine sensors. [Abstract]2024 Dec 23:2024.12.22.629999. PMID: 39763912
Purity & Documentation
References
[1]. Bourne JA. SCH 23390: the first selective dopamine D1-like receptor antagonist. CNS Drug Rev. 2001 Winter;7(4):399-414. [Content Brief]
[2]. Millan MJ, et al. The "selective" dopamine D1 receptor antagonist, SCH23390, is a potent and high efficacy agonist at cloned human serotonin2C receptors. Psychopharmacology (Berl). 2001 Jun;156(1):58-62. [Content Brief]
[3]. Kuzhikandathil EV, et al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26. [Content Brief]
[4]. Wang YH, et al. Isosibiricin inhibits microglial activation by targeting the dopamine D1/D2 receptor-dependent NLRP3/caspase-1 inflammasome pathway. Acta Pharmacol Sin. 2020 Feb;41(2):173-180. [Content Brief]
[5]. Crockett SL, et al. Role of dopamine and selective dopamine receptor agonists on mouse ductus arteriosus tone and responsiveness. Pediatr Res. 2019 Dec 9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SCH-23390 maleate Related Classifications
HY-108400 Related Classifications
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