87075-17-0
Chemical Structure
SCH-23390
Synonym(s): R-(+)-SCH-23390
- CAS No.: 87075-17-0
- Formula:C17H18ClNO
- Molecular Weight:287.78
IUPAC Name: (R)-8-chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol
InChIKey: GOTMKOSCLKVOGG-OAHLLOKOSA-N
SMILES: OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1
Biological Activity: SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system[1][2].
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SCH-23390 | SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline (HY-B0726A) and strychnine, and is used in research on neurological disorders related to the dopamine system. | |||||||||||||||||||||
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- [1]. Dakota B Zinani, et al. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Sci Rep. 2023 Sep 4;13(1):14566. [Content Brief]
- [2]. J A Bourne, et al. SCH 23390: the first selective dopamine D1-like receptor antagonist. [Content Brief]
Keywords
