1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Anti-infection
  2. Dopamine Receptor
    Histamine Receptor
    Bacterial
  3. Chlorprothixene

Chlorprothixene 

Cat. No.: HY-B0274 Purity: 99.13%
Handling Instructions

Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.

For research use only. We do not sell to patients.

Chlorprothixene Chemical Structure

Chlorprothixene Chemical Structure

CAS No. : 113-59-7

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Description

Chlorprothixene is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

IC50 & Target[1]

Human D1 Receptor

18 nM (Ki)

Human D2 Receptor

2.96 nM (Ki)

Human D3 Receptor

4.56 nM (Ki)

Human D5 Receptor

9 nM (Ki)

Human H1 Receptor

3.75 nM (Ki)

In Vitro

Chlorprothixene binds to 5-HT receptors with pKis of 8.3, 8.5, and 9.4 for 5-HT7, 5-HT6 and 5-HT2, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

315.86

Formula

C₁₈H₁₈ClNS

CAS No.

113-59-7

SMILES

CN(C)CC/C=C1C2=C(SC3=C\1C=CC=C3)C=CC(Cl)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 33.33 mg/mL (105.52 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1660 mL 15.8298 mL 31.6596 mL
5 mM 0.6332 mL 3.1660 mL 6.3319 mL
10 mM 0.3166 mL 1.5830 mL 3.1660 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.91 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

ChlorprothixeneDopamine ReceptorHistamine ReceptorBacterialInhibitorinhibitorinhibit

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