1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
    Anti-infection
  2. Dopamine Receptor
    Histamine Receptor
    Bacterial
  3. Chlorprothixene hydrochloride

Chlorprothixene hydrochloride 

Cat. No.: HY-B0274A Purity: ≥98.0%
Handling Instructions

Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity.

For research use only. We do not sell to patients.

Chlorprothixene hydrochloride Chemical Structure

Chlorprothixene hydrochloride Chemical Structure

CAS No. : 6469-93-8

Size Price Stock Quantity
50 mg USD 60 In-stock
Estimated Time of Arrival: December 31
100 mg USD 84 In-stock
Estimated Time of Arrival: December 31
200 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 216 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Chlorprothixene hydrochloride:

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Description

Chlorprothixene hydrochloride is a dopamine and histamine receptors antagonist with Kis of 18 nM, 2.96 nM, 4.56 nM, 9 nM and 3.75 nM for hD1, hD2, hD3, hD5 and hH1 receptors, respectively. Antipsychotic activity[1].

IC50 & Target[1]

Human D1 Receptor

18 nM (Ki)

Human D2 Receptor

2.96 nM (Ki)

Human D3 Receptor

4.56 nM (Ki)

Human D5 Receptor

9 nM (Ki)

Human H1 Receptor

3.75 nM (Ki)

In Vitro

Chlorprothixene binds to 5-HT receptors with pKis of 8.3, 8.5, and 9.4 for 5-HT7, 5-HT6 and 5-HT2, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

352.32

Formula

C₁₈H₁₉Cl₂NS

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (141.92 mM; Need ultrasonic)

Ethanol : 25 mg/mL (70.96 mM; Need ultrasonic)

DMSO : 2.5 mg/mL (7.10 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8383 mL 14.1916 mL 28.3833 mL
5 mM 0.5677 mL 2.8383 mL 5.6767 mL
10 mM 0.2838 mL 1.4192 mL 2.8383 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% EtOH    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.10 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Chlorprothixene hydrochloride
Cat. No.:
HY-B0274A
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