1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor
  3. Tetrahydroberberine

Tetrahydroberberine  (Synonyms: Canadine)

Cat. No.: HY-N0925 Purity: 99.65%
COA Handling Instructions

Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach.

For research use only. We do not sell to patients.

Tetrahydroberberine Chemical Structure

Tetrahydroberberine Chemical Structure

CAS No. : 522-97-4

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10 mM * 1 mL in DMSO
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Based on 1 publication(s) in Google Scholar

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Description

Tetrahydroberberine is a different kind of living thing that can be extended and divided into parts. Tetrahydroberberine is a kind of effective D2 receptor antagonistic force. Tetrahydroberberine has the ability to strengthen the stomach and relieve the pressure on the stomach[1][2][3].

In Vitro

Tetrahydroberberine (100 μM) blocks K(ATP) channels in sharply isolated dopaminergic (DA) neurons in rat substantia nigra pars compacta (SNc) and restores membrane hyperpolarization induced by 1 μM rotenone (HY-B1756)[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Tetrahydroberberine (30 μg/kg; IV) causes a dramatic increase in gastric regulatory capacity in beagle dogs, significantly enhances gastric contractility and shortens contraction intervals in rats, and enhances gastric motility function in the upper gastrointestinal tract[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

339.39

Formula

C20H21NO4

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

COC1=CC=C(CC23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC

Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (73.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9465 mL 14.7323 mL 29.4646 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9465 mL 14.7323 mL 29.4646 mL 73.6616 mL
5 mM 0.5893 mL 2.9465 mL 5.8929 mL 14.7323 mL
10 mM 0.2946 mL 1.4732 mL 2.9465 mL 7.3662 mL
15 mM 0.1964 mL 0.9822 mL 1.9643 mL 4.9108 mL
20 mM 0.1473 mL 0.7366 mL 1.4732 mL 3.6831 mL
25 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9465 mL
30 mM 0.0982 mL 0.4911 mL 0.9822 mL 2.4554 mL
40 mM 0.0737 mL 0.3683 mL 0.7366 mL 1.8415 mL
50 mM 0.0589 mL 0.2946 mL 0.5893 mL 1.4732 mL
60 mM 0.0491 mL 0.2455 mL 0.4911 mL 1.2277 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Tetrahydroberberine
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