1. Membrane Transporter/Ion Channel
    Neuronal Signaling
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
    PI3K/Akt/mTOR
  2. TRP Channel
    Reactive Oxygen Species
    Apoptosis
    Caspase
    Bcl-2 Family
    Akt
    PI3K
  3. Dihydrocapsaicin

Dihydrocapsaicin 

Cat. No.: HY-N0361 Purity: 98.82%
COA Handling Instructions

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat.

For research use only. We do not sell to patients.

Dihydrocapsaicin Chemical Structure

Dihydrocapsaicin Chemical Structure

CAS No. : 19408-84-5

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10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 190 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Dihydrocapsaicin, a capsaicin, is a potent and selective TRPV1 (transient receptor potential vanilloid channel 1) agonist. Dihydrocapsaicin reduces AIF, Bax, and Caspase-3 expressions, and increased Bcl-2, Bcl-xL and p-Akt levels. Dihydrocapsaicin enhances the hypothermia-induced neuroprotection following ischemic stroke via PI3K/Akt regulation in rat[1][2][3].

IC50 & Target

TRPV1

 

PI3K

 

Caspase 3

 

Bax

 

Bcl-2

 

Bcl-xL

 

In Vitro

Dihydrocapsaicin (0-100 μM) inhibits platelet aggregation and the activity of clotting factors VIII:C (6.26-100 μM) and IX (25-100 μM)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dihydrocapsaicin (0.5 mg/kg, IP, once) exhibits hypothermic effect and neuroprotection in rat MCAO models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats (adult, male, 300-340 g, subjected to right middle cerebral artery occlusion (MCAO)[2]
Dosage: 0.5 mg/kg
Administration: IP, once
Result: Exhibits hypothermic effect, rectal temperature dropped to approximately 35.0 ℃ at 30 min, stayed at equal or below 35.0 ℃ for approximately 20 min, and then gradually returned to approximately 36.5 ℃ at 120 min. Significantly reduced Ischemia-reperfusion induced infarct volume (36.2% ± 2.5%). Reduces ROS levels at 24 h, and reduced ischemia-reperfusion induced a high level of cell death.
Molecular Weight

307.43

Formula

C18H29NO3

CAS No.
SMILES

CC(C)CCCCCCC(NCC1=CC=C(O)C(OC)=C1)=O

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (813.19 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2528 mL 16.2639 mL 32.5277 mL
5 mM 0.6506 mL 3.2528 mL 6.5055 mL
10 mM 0.3253 mL 1.6264 mL 3.2528 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (20.33 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (20.33 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 6.25 mg/mL (20.33 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Product Name:
Dihydrocapsaicin
Cat. No.:
HY-N0361
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