1. Others GPCR/G Protein Neuronal Signaling
  2. Isotope-Labeled Compounds Dopamine Receptor
  3. Pramipexole-d5 dihydrochloride

Pramipexole-d5 (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

For research use only. We do not sell to patients.

Pramipexole-d<sub>5</sub> dihydrochloride Chemical Structure

Pramipexole-d5 dihydrochloride Chemical Structure

CAS No. : 1217601-58-5

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Based on 1 publication(s) in Google Scholar

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Description

Pramipexole-d5 (dihydrochloride) is deuterium labeled Pramipexole (dihydrochloride). Pramipexole dihydrochloride is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS)[1][2][3].

IC50 & Target

D2 Receptor

 

D3 Receptor

 

D4 Receptor

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

289.28

Formula

C10H14D5Cl2N3S

CAS No.
SMILES

NC1=NC2=C(S1)C[C@H](CC2)NCC([2H])([2H])C([2H])([2H])[2H].Cl.Cl

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Pramipexole-d5 dihydrochloride
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HY-17355S1
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