1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
    Adrenergic Receptor
    Sigma Receptor
  3. Blonanserin

Blonanserin (Synonyms: AD-5423)

Cat. No.: HY-13575 Purity: 99.77%
Handling Instructions

Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension.

For research use only. We do not sell to patients.

Blonanserin Chemical Structure

Blonanserin Chemical Structure

CAS No. : 132810-10-7

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
25 mg USD 103 In-stock
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100 mg USD 264 In-stock
Estimated Time of Arrival: December 31
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Description

Blonanserin (AD-5423) is a potent and orally active 5-HT2A (Ki=0.812 nM) and dopamine D2 receptor (Ki =0.142 nM) antagonist. Blonanserin is usually acts as an atypical antipsychotic agent and can be used for the research of extrapyramidal symptoms, excessive sedation, or hypotension[1].

IC50 & Target[1][2]

D2 Receptor

0.142 nM (Ki)

D3 Receptor

0.494 nM (Ki)

D4 Receptor

150 nM (Ki)

D1 Receptor

1070 nM (Ki)

5-HT2A Receptor

0.812 nM (Ki)

5-HT2C Receptor

26.4 nM (Ki)

5-HT6 Receptor

11.7 nM (Ki)

α1-adrenergic receptor

26.7 (Rat nM (Ki)

α2-adrenergic receptor

530 (Rat c nM (Ki)

In Vitro

Blonanserin exerts some blockade of α1-adrenergic receptors (Ki=26.7 nM) and also shows significant affinity for the D3 receptor (Ki=0.494 nM). Blonanserin possesses low affinity for the sigma receptor (IC50=286 nM), but lacks significant affinity for numerous other sites including the 5-HT1A, 5-HT3, D1, α2-adrenergic, β-adrenergic, H1, and mACh receptors and the monoamine transporters[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Blonanserin (oral gavage; 1 mg/kg; 14 days) significantly ameliorates the social deficit observed in PCP-administered mice and inhibits the decrease in the levels of Ser897-phosphorylation, but preatment with blonanserin does not affect the social behaviors in saline-administered mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice received saline or phencyclidine once a day for 14 consecutive days[2]
Dosage: 1 mg/kg
Administration: Oral gavage; 1 mg/kg; 14 days
Result: Had an effect on the social deficit in mice that received repeated PCP administration
Clinical Trial
Molecular Weight

367.50

Formula

C₂₃H₃₀FN₃

CAS No.

132810-10-7

SMILES

FC1=CC=C(C2=C(CCCCCC3)C3=NC(N4CCN(CC)CC4)=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 14.29 mg/mL (38.88 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7211 mL 13.6054 mL 27.2109 mL
5 mM 0.5442 mL 2.7211 mL 5.4422 mL
10 mM 0.2721 mL 1.3605 mL 2.7211 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.43 mg/mL (3.89 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.43 mg/mL (3.89 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.43 mg/mL (3.89 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BlonanserinAD-5423AD5423AD 54235-HT ReceptorDopamine ReceptorAdrenergic ReceptorSigma ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorBeta Receptorantipsychoticschizophrenia.?extrapyramidal symptomexcessive?sedationhypotensionsocial deficitInhibitorinhibitorinhibit

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