1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. 5-HT Receptor
    Histamine Receptor
  3. Pimethixene maleate

Pimethixene maleate (Synonyms: Pimetixene maleate)

Cat. No.: HY-B1101A
Handling Instructions

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

For research use only. We do not sell to patients.

Pimethixene maleate Chemical Structure

Pimethixene maleate Chemical Structure

CAS No. : 13187-06-9

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Description

Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

IC50 & Target[1]

H1 receptor

10.14 (pKi)

5-HT2B Receptor

10.44 (pKi)

5-HT2A Receptor

10.22 (pKi)

5-HT2C Receptor

8.42 (pKi)

5-HT1A Receptor

7.63 (pKi)

M2 receptor

9.38 (pKi)

M1 receptor

8.61 (pKi)

D2 receptor

8.19 (pKi)

DD4.4 receptor

7.54 (pKi)

Molecular Weight

409.50

Formula

C₂₃H₂₃NO₄S

CAS No.

13187-06-9

SMILES

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3.OC(/C=C\C(O)=O)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Pimethixene maleate
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