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Pivagabine (Synonyms: CXB-722)

Cat. No.: HY-108295
Handling Instructions

Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain.

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Pivagabine Chemical Structure

Pivagabine Chemical Structure

CAS No. : 69542-93-4

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10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
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Description

Pivagabine (CXB 722) is a hydrophobic 4-aminobutyric acid derivative with neuromodulatory activity. Pivagabine penetrates the blood-brain barrier in rats. Pivagabine antagonizes the effects of foot shock on both GABAA receptor function and corticotropin-releasing factor (CRF) concentrations in rat brain[1][2].

In Vivo

Pivagabine (CXB 722) (200 mg/kg; i.p.; twice a day for 4 days and 1 hour before killing on the 5th day) prevents the effects of foot-shock stress on CRF concentration in both brain regions[2].

Animal Model: Adult male Sprague-Dawley CD rats (200-250 g)[2]
Dosage: 200 mg/kg
Administration: i.p.; twice a day for 4 days and 1 hour before killing on the 5th day
Result: Prevented the effects of foot-shock stress on CRF concentration in both brain regions. Reduced by 52% the CRF concentration in the hypothalamus but had no effect on that in the cerebral cortex.
Molecular Weight

187.24

Formula

C₉H₁₇NO₃

CAS No.

69542-93-4

SMILES

O=C(O)CCCNC(C(C)(C)C)=O

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Keywords:

PivagabineCXB-722CXB722CXB 722Otherspsychoactivederivativeneuromodulatoryblood-brainbarrierfootshockcorticotropin-releasingfactorInhibitorinhibitorinhibit

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Pivagabine
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HY-108295
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