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Dexrazoxane (Synonyms: ICRF-187; ADR-529; NSC-169780)

Cat. No.: HY-B0581
Handling Instructions

Dexrazoxane (ICRF-187) is a cardioprotective agent.

For research use only. We do not sell to patients.

Dexrazoxane Chemical Structure

Dexrazoxane Chemical Structure

CAS No. : 24584-09-6

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Description

Dexrazoxane (ICRF-187) is a cardioprotective agent. Target: Others Dexrazoxane is a cardioprotective agent. Dexrazoxane is a derivative of EDTA, dexrazoxane chelates iron and thus reduces the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. The exact chelation mechanism is unknown, but it has be postulated that dexrazoxane can be converted into ring-opened form intracellularly and interfere with iron-mediated free radical generation that is in part thought to be responsible for anthryacycline induced cadiomyopathy. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs [1, 2].

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Molecular Weight

268.27

Formula

C₁₁H₁₆N₄O₄

CAS No.

24584-09-6

SMILES

C[[email protected]](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

DexrazoxaneICRF-187ADR-529NSC-169780ICRF187ICRF 187ADR529ADR 529NSC169780NSC 169780OthersInhibitorinhibitorinhibit

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