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Dexrazoxane hydrochloride (Synonyms: ICRF-187 hydrochloride; ADR-529 Hydrochloride)

Cat. No.: HY-76201 Purity: 99.96%
Handling Instructions

Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a cardioprotective agent.

For research use only. We do not sell to patients.

Dexrazoxane hydrochloride Chemical Structure

Dexrazoxane hydrochloride Chemical Structure

CAS No. : 149003-01-0

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
10 mg USD 60 In-stock
Estimated Time of Arrival: December 31
50 mg USD 114 In-stock
Estimated Time of Arrival: December 31
100 mg USD 156 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Other Forms of Dexrazoxane hydrochloride:

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a cardioprotective agent.

IC50 & Target

As a derivative of EDTA, dexrazoxane chelates iron, thus reduce the number of metal ions complexed with anthracycline and, consequently, decrease the formation of superoxide radicals. This agent is used to protect the heart against the cardiotoxic side effects of anthracyclines, such as doxorubicin. It was speculated that dexrazoxane could be used for further investigation to synthesize new antimalarial drugs.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (Need ultrasonic)

H2O : 20 mg/mL (Need ultrasonic)

In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 3 mg/mL (Infinity mM); Clear solution

References
CAS No.

149003-01-0

SMILES

C[[email protected]](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O.[xHCl]

Storage

4°C, protect from light

Shipping

Room temperature in continental US; may vary elsewhere

Purity: 99.96%

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Dexrazoxane hydrochloride
Cat. No.:
HY-76201
Quantity:

Dexrazoxane hydrochloride

Cat. No.: HY-76201