149003-01-0
Chemical Structure
Dexrazoxane hydrochloride
Synonym(s): ICRF-187 hydrochloride; ADR-529 hydrochloride; NSC-169780 hydrochloride
- CAS No.: 149003-01-0
- Formula:C11H18Cl2N4O4
- Molecular Weight:341.19
IUPAC Name: (S)-4,4'-(propane-1,2-diyl)bis(piperazine-2,6-dione) dihydrochloride
InChIKey: YLJFHOXVLTVWCQ-KLXURFKVSA-N
SMILES: C[C@H](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O.[H]Cl.[H]Cl
Biological Activity: Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases[1][2][3][4].
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Dexrazoxane hydrochloride | 99.83% | Dexrazoxane hydrochloride (ICRF-187 hydrochloride) is a heart protectant that can help preserve ovarian function and fertility. Dexrazoxane hydrochloride has antioxidant and anti-inflammatory properties, can cross the blood-brain barrier, improves motor function disorders, and offers neuroprotective effects, making it useful in the study of neurodegenerative diseases. | ||||||||||||||||||||
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References
- [1]. Shiwei Deng, et al. The catalytic topoisomerase II inhibitor dexrazoxane induces DNA breaks, ATF3 and the DNA damage response in cancer cells. Br J Pharmacol. 2015 May;172(9):2246-57. [Content Brief]
- [2]. Jenna Kropp, et al. Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice. PLoS One. 2015 Nov 6;10(11):e0142588. [Content Brief]
- [3]. A R Imondiv, et al. Dose-response relationship of dexrazoxane for prevention of doxorubicin-induced cardiotoxicity in mice, rats, and dogs. Cancer Res. 1996 Sep 15;56(18):4200-4. [Content Brief]
- [4]. Meng Mei, et al. Antioxidant and anti-inflammatory effects of dexrazoxane on dopaminergic neuron degeneration in rodent models of Parkinson's disease. Neuropharmacology. 2019 Dec 1:160:107758. [Content Brief]
