Dexrazoxane monohydrochloride

Cat. No.: HY-110075: Data Sheet
SDS
Handling Instructions
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Dexrazoxane monohydrochloride is the hydrochloride of Dexrazoxane (HY-B0581). Dexrazoxane can prevent or reduce cardiac damage and is an iron chelator and apoptosis inducer. Dexrazoxane has cardioprotective, anti-inflammatory, antioxidant, anti-tumor and neuroprotective activities and inhibits ferroptosis.

For research use only. We do not sell to patients.

CAS No. : 1263283-43-7

Size	Stock	Quantity
10 mg	Get quote 3 - 4 weeks 4 - 5 weeks 5 - 6 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Customer Review

Based on 14 publication(s) in Google Scholar

Other Forms of Dexrazoxane monohydrochloride:

Dexrazoxane In-stock

14 Publications Citing Use of MCE Dexrazoxane monohydrochloride

Bio/Physico-chemical Assay

Flow Cytometry

Cell Imaging/Staining

RT-PCR

In Vivo Efficacy Study

: Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]; Dexrazoxane (DXZ) (1 µM; 24 h) resulted in a decline in contractile speed in NMCMs.

: Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]; Dexrazoxane (DXZ) (1 µM; 24 h) resulted in a decline in cell viability in NMCMs.

: Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]; Dexrazoxane (DXZ) (1 µM; 24 h) inhibited DOX-induced iron accumulation and ROS and restored mitochondrial membrane potential in NMCMs.

: Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]; Dexrazoxane (DXZ) (1 µM; 24 h) reversed Ptgs2 mRNA expression in NMCMs.

: Dexrazoxane monohydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2023 May;10(15):e2206007. [Abstract]; Dexrazoxane (DXZ) (20 mg/kg; i.p.; weekly for 4 weeks) reversed the DOX-induced decrease in body weight and the ratio of heart weight to tibia length (HW/TL) of chronic DoIC (doxorubicin (DOX)-induced cardiotoxicity) mice.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Clinical Trial

Molecular Weight

304.73

Formula

C₁₁H₁₇ClN₄O₄

CAS No.

1263283-43-7

SMILES

C[C@H](N(C1)CC(NC1=O)=O)CN(C2)CC(NC2=O)=O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Data Sheet (269 KB) SDS (252 KB) Handling Instructions (2659 KB)

References

[1]. Lipshultz SE, et al. The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med. 2004 Jul 8;351(2):145-53. [Content Brief]