2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Perospirone

Perospirone  (Synonyms: SM-9018 free base)

Cat. No.: HY-B0731A Purity: 99.43%
COA Handling Instructions

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

For research use only. We do not sell to patients.

Perospirone Chemical Structure

Perospirone Chemical Structure

CAS No. : 150915-41-6

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Solution
10 mM * 1 mL in DMSO USD 85 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 85 In-stock
Solid
5 mg USD 77 In-stock
10 mg USD 132 In-stock
50 mg USD 462 In-stock
100 mg USD 792 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Perospirone:

Perospirone Related Antibodies

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5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT2A Receptor

0.6 nM (Ki)

Dopamine D2

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

Dopamine D1

41 nM (Ki)

In Vitro

Perospirone (SM-9018 free base) possesses moderate affinities for α1, 5-HT1, and D1 receptors (Ki=17, 18 and 41 nM, respectively) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Perospirone Related Antibodies
In Vivo

Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (6 weeks old) weighing 25-30 g[2]
Dosage: 1.0, 3.0 or 10.0 mg/kg
Administration: Orally; daily; for 14 consecutive days
Result: Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner.
Clinical Trial
Molecular Weight

426.57

Appearance

Solid

Formula

C23H30N4O2S
CAS No.
SMILES

O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3443 mL 11.7214 mL 23.4428 mL
5 mM 0.4689 mL 2.3443 mL 4.6886 mL
10 mM 0.2344 mL 1.1721 mL 2.3443 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Perospirone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Perospirone150915-41-6SM-9018SM9018SM 90185-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrallyatypicalantipsychoticschizophrenicdiseasecognitivedeficitsInhibitorinhibitorinhibit

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