1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Perospirone

Perospirone (Synonyms: SM-9018 free base)

Cat. No.: HY-B0731A Purity: 99.51%
Handling Instructions

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

For research use only. We do not sell to patients.

Perospirone Chemical Structure

Perospirone Chemical Structure

CAS No. : 150915-41-6

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10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
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10 mg USD 120 In-stock
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50 mg USD 420 In-stock
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100 mg USD 720 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT2A Receptor

0.6 nM (Ki)

Dopamine D2

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

Dopamine D1

41 nM (Ki)

In Vitro

Perospirone (SM-9018 free base) possesses moderate affinities for α1, 5-HT1, and D1 receptors (Ki=17, 18 and 41 nM, respectively) [1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (6 weeks old) weighing 25-30 g[2]
Dosage: 1.0, 3.0 or 10.0 mg/kg
Administration: Orally; daily; for 14 consecutive days
Result: Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner.
Molecular Weight

426.57

Formula

C₂₃H₃₀N₄O₂S

CAS No.

150915-41-6

SMILES

O=C([[email protected]@]1([H])[[email protected]]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References
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Keywords:

PerospironeSM-9018SM9018SM 90185-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrallyatypicalantipsychoticschizophrenicdiseasecognitivedeficitsInhibitorinhibitorinhibit

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Perospirone
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HY-B0731A
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