Perospirone hydrochloride
Based on 1 Customer Validation
Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 129273-38-7
- Formula: C23H31ClN4O2S
- Molecular Weight:463.04
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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5-HT1A Receptor |
5-HT2A Receptor |
5-HT2A Receptor 0.6 nM (Ki) |
D2 Receptor 1.4 nM (Ki) |
5-HT1A Receptor 2.9 nM (Ki) |
5-HT1 Receptor 18 nM (Ki) |
D1 Receptor 41 nM (Ki) |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 129273-38-7
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Appearance Solid
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Molecular Weight 463.04
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Formula C23H31ClN4O2S
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Color White to off-white
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SMILES
[H]Cl.O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3
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Synonyms
SM-9018
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 125 mg/mL (269.96 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (392 KB)
- English - EN (392 KB)
- Français - FR (392 KB)
- Deutsch - DE (392 KB)
- Norwegian - NO (392 KB)
- Español - ES (392 KB)
- Swedish - SV (392 KB)
- Italian - IT (392 KB)
- Korean - KR (392 KB)
- Portuguese - PT (392 KB)
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Handling Instructions (2659 KB)
References
[1]. Kato T, et al. Binding profile of SM-9018, a novel antipsychotic candidate. pn J Pharmacol. 1990 Dec;54(4):478-81. [Content Brief]
[2]. Hagiwara H, et al. Phencyclidine-induced cognitive deficits in mice are improved by subsequent subchronic administration of the antipsychotic drug perospirone: role of serotonin 5-HT1A receptors. Eur Neuropsychopharmacol. 2008 Jun;18(6):448-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1596 mL | 10.7982 mL | 21.5964 mL | 53.9910 mL |
| 5 mM | 0.4319 mL | 2.1596 mL | 4.3193 mL | 10.7982 mL | |
| 10 mM | 0.2160 mL | 1.0798 mL | 2.1596 mL | 5.3991 mL | |
| 15 mM | 0.1440 mL | 0.7199 mL | 1.4398 mL | 3.5994 mL | |
| 20 mM | 0.1080 mL | 0.5399 mL | 1.0798 mL | 2.6996 mL | |
| 25 mM | 0.0864 mL | 0.4319 mL | 0.8639 mL | 2.1596 mL | |
| 30 mM | 0.0720 mL | 0.3599 mL | 0.7199 mL | 1.7997 mL | |
| 40 mM | 0.0540 mL | 0.2700 mL | 0.5399 mL | 1.3498 mL | |
| 50 mM | 0.0432 mL | 0.2160 mL | 0.4319 mL | 1.0798 mL | |
| 60 mM | 0.0360 mL | 0.1800 mL | 0.3599 mL | 0.8999 mL | |
| 80 mM | 0.0270 mL | 0.1350 mL | 0.2700 mL | 0.6749 mL | |
| 100 mM | 0.0216 mL | 0.1080 mL | 0.2160 mL | 0.5399 mL |
Perospirone hydrochloride Related Classifications
HY-B0731 Related Classifications
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