1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
    Dopamine Receptor
  3. Perospirone hydrochloride

Perospirone hydrochloride (Synonyms: SM-9018)

Cat. No.: HY-B0731
Handling Instructions

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

For research use only. We do not sell to patients.

Perospirone hydrochloride Chemical Structure

Perospirone hydrochloride Chemical Structure

CAS No. : 129273-38-7

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Description

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT2A Receptor

0.6 nM (Ki)

D2 Receptor

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

D1 Receptor

41 nM (Ki)

Molecular Weight

463.04

Formula

C₂₃H₃₁ClN₄O₂S

CAS No.

129273-38-7

SMILES

[H]Cl.O=C([[email protected]@]1([H])[[email protected]]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PerospironeSM-9018SM9018SM 90185-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrallyatypicalantipsychoticschizophrenicdiseasecognitive5-HT2A5-HT1AD2-receptorInhibitorinhibitorinhibit

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Perospirone hydrochloride
Cat. No.:
HY-B0731
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