1. GPCR/G Protein Neuronal Signaling
  2. 5-HT Receptor Dopamine Receptor
  3. Perospirone hydrochloride

Perospirone hydrochloride  (Synonyms: SM-9018)

Cat. No.: HY-B0731 Purity: 99.94%
COA Handling Instructions

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

For research use only. We do not sell to patients.

Perospirone hydrochloride Chemical Structure

Perospirone hydrochloride Chemical Structure

CAS No. : 129273-38-7

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Perospirone hydrochloride:

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Description

Perospirone hydrochloride (SM-9018) is an orally active antagonist of 5-HT2A receptor (Ki of 0.6 nM) and dopamine D2 receptor (Ki of 1.4 nM). Perospirone hydrochloride is also a partial agonist of 5-HT1A receptor (Ki of 2.9 nM). Perospirone hydrochloride is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT2A Receptor

0.6 nM (Ki)

D2 Receptor

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

D1 Receptor

41 nM (Ki)

Clinical Trial
Molecular Weight

463.04

Formula

C23H31ClN4O2S

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H]Cl.O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (269.96 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1596 mL 10.7982 mL 21.5964 mL
5 mM 0.4319 mL 2.1596 mL 4.3193 mL
10 mM 0.2160 mL 1.0798 mL 2.1596 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation
References
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Perospirone hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Perospirone hydrochloride
Cat. No.:
HY-B0731
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