1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. WAY-100135 dihydrochloride

WAY-100135 dihydrochloride 

Cat. No.: HY-117575A
Handling Instructions

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties.

For research use only. We do not sell to patients.

WAY-100135 dihydrochloride Chemical Structure

WAY-100135 dihydrochloride Chemical Structure

CAS No. : 149055-79-8

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Description

WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2].

IC50 & Target[1]

5-HT1A Receptor

34 nM (IC50)

In Vitro

WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2 of 7.2[1].
WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1].
WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

468.46

Formula

C₂₄H₃₅Cl₂N₃O₂

CAS No.
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Storage

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WAY-100135 dihydrochloride
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HY-117575A
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