SKF 38393 hydrochloride
Based on 24 publication(s) in Google Scholar
SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.
For research use only. We do not sell to patients.
- Purity: 99.49%
- CAS No.: 62717-42-4
- Formula: C16H18ClNO2
- Molecular Weight:291.77
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
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Publications Citing Use of MedChemExpress (MCE) SKF 38393 hydrochloride
More- Nat Commun. 2024 May 1;15(1):3685. [Abstract]
- Neuron. 2026 May 19:S0896-6273(26)00332-6. [Abstract]
- Neuron. 2024 Apr 3;112(7):1150-1164.e6. [Abstract]
- Microbiome. 2020 Aug 20;8(1):120. [Abstract]
- J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]
- Adv Sci (Weinh). 2026 Jul;13(37):e19913. [Abstract]
- Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]
- J Neuroinflammation. 2026 Apr 23. [Abstract]
- Acta Pharmacol Sin. 2026 Apr 24. [Abstract]
- Acta Pharmacol Sin. 2025 May 6. [Abstract]
- Free Radic Biol Med. 2023 Jun:202:2-16. [Abstract]
- Cell Rep. 2025 Mar 1;44(3):115364. [Abstract]
- EMBO Rep. 2022 Feb 3;23(3):e53191. [Abstract]
- Eur J Pharmacol. 2024 Oct 15:981:176866. [Abstract]
- J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]
- Biomedicines. 2024 May 9;12(5):1046. [Abstract]
- Aquaculture. 2025 Apr 15.
- Insect Biochem Mol Biol. 2025 May:180:104312. [Abstract]
- Neurobiol Aging. 2021 Jun:102:1-16. [Abstract]
- Behav Brain Res. 2022 Mar 26:422:113759. [Abstract]
- Med Sci Monit. 2021 Oct 18;27:e933278. [Abstract]
- bioRxiv. 2026 Jan 6:2026.01.06.697936. [Abstract]
- bioRxiv. 2020 Jun.
- bioRxiv. 2019 Oct.
Customer Validation & Images
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In Vivo Efficacy Study
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Bio/Physico-chemical Assay
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In Vivo Efficacy Study
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WB
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In Vivo Efficacy Study
All Dopamine Receptor Isoforms
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Biological Activity
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D1 Receptor |
SKF-38393 hydrochloride induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:GC cells
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Concentration:10 μmol/L
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Incubation Time:1 hour
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Result:Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
SKF-38393 hydrochloride attenuates MPTP-induced depletion of dopamine[3].
SKF-38393 hydrochloride enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF-38393 hydrochloride enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Balb/c mice ( 20-25 g)[3].
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Dosage:5 mg/kg, 10 mg/kg
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Administration:Intraperitoneal injection
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Result:Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
Chemical Information
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CAS No. 62717-42-4
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Appearance Solid
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Molecular Weight 291.77
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Formula C16H18ClNO2
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Color Light yellow to khaki
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SMILES
OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl
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Synonyms
(±)-SKF-38393 hydrochloride; SKF-38393A
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (24)
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Journal Impact Factor
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Most Recent
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Nat Commun
Large-language models facilitate discovery of the molecular signatures regulating sleep and activity. [Abstract]2024 May 1;15(1):3685. PMID: 38693116 -
Neuron
Hyperexcitable VTA-mPFC dopaminergic circuit disrupts sleep spindle and mediates sleep fragmentation after chronic social defeat stress. [Abstract]2026 May 19:S0896-6273(26)00332-6. PMID: 42161276 -
Neuron
The Calmodulin-interacting peptide Pcp4a regulates feeding state-dependent behavioral choice in zebrafish. [Abstract]2024 Apr 3;112(7):1150-1164.e6. PMID: 38295792 -
Microbiome
The gut microbiota regulates autism-like behavior by mediating vitamin B6 homeostasis in EphB6-deficient mice. [Abstract]2020 Aug 20;8(1):120. PMID: 32819434
SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]
After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.
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J Clin Invest
A midbrain-cortical circuit mediated by a claustrum neuronal ensemble orchestrates drug-paired context memory processing. [Abstract]2026 Jan 15;136(5):e196944. PMID: 41538288
SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]
SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.
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Adv Sci (Weinh)
Nigra-Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice. [Abstract]2026 Jul;13(37):e19913. PMID: 41944312 -
Adv Sci (Weinh)
Corticosterone Contributes to Context-Triggered Retrieval of Morphine Withdrawal Memories by Acting on Basolateral Amygdala Neurons Projecting to Nucleus Accumbens Core. [Abstract]2025 Aug 23:e03409. PMID: 40847673
SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]
SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.
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J Neuroinflammation
Dopamine signaling governs macrophage-mediated acute lung injury through JAML/IL-10-coupled mitochondrial regulation. [Abstract]2026 Apr 23. PMID: 42026623 -
Acta Pharmacol Sin
Dopamine abrogates immunosuppression mediated by PD-L1 of cancer stem cells in a preclinical triple-negative breast cancer model. [Abstract]2026 Apr 24. PMID: 42032133 -
Acta Pharmacol Sin
Dysfunction of subthalamic dopaminergic circuitry contributes to anxiety- and depression-like behaviors in 6-OHDA lesion-induced hemiparkinsonian mice. [Abstract]2025 May 6. PMID: 40329003
SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6. [Abstract]
SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.
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Free Radic Biol Med
Dopamine D1 receptor agonist alleviates acute lung injury via modulating inflammatory responses in macrophages and barrier function in airway epithelial cells. [Abstract]2023 Jun:202:2-16. PMID: 36965538 -
Cell Rep
2025 Mar 1;44(3):115364. PMID: 40023842 -
EMBO Rep
ZFP207 sustains pluripotency by coordinating OCT4 stability, alternative splicing and RNA export. [Abstract]2022 Feb 3;23(3):e53191. PMID: 35037361 -
Eur J Pharmacol
The role of heterodimers formed by histamine H3 receptors and dopamine D1 receptors on the methamphetamine-induced conditioned place preference. [Abstract]2024 Oct 15:981:176866. PMID: 39089461 -
J Affect Disord
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity. [Abstract]2024 Jul 1:356:586-596. PMID: 38657764
SKF 38393 hydrochloride purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]
SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.
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Biomedicines
Enhancing Osteogenic Potential: Controlled Release of Dopamine D1 Receptor Agonist SKF38393 Compared to Free Administration. [Abstract]2024 May 9;12(5):1046. PMID: 38791008 -
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Insect Biochem Mol Biol
Molecular and pharmacological characterization of the dopamine receptors in the oriental fruit fly, Bactrocera dorsalis. [Abstract]2025 May:180:104312. PMID: 40245998 -
Neurobiol Aging
Dopaminergic modulation of working memory and cognitive flexibility in a zebrafish model of aging-related cognitive decline. [Abstract]2021 Jun:102:1-16. PMID: 33676049 -
Behav Brain Res
Activation of dopamine D2 receptors in the shell of nucleus accumbens triggers conditioned avoidance responses in rats. [Abstract]2022 Mar 26:422:113759. PMID: 35051488 -
Med Sci Monit
Salicylate Induced GABAAR Internalization by Dopamine D1-Like Receptors Involving Protein Kinase C (PKC) in Spiral Ganglion Neurons. [Abstract]2021 Oct 18;27:e933278. PMID: 34657931 -
bioRxiv
Host GPCR-cAMP signaling balances Gαs and Gαi activity to control intracellular Brucella infection. [Abstract]2026 Jan 6:2026.01.06.697936. PMID: 41542404 -
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Solvent & Solubility
DMSO : 125 mg/mL (428.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 10 mg/mL (34.27 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (7.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (7.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (284 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Altar CA, et al. Picomolar affinity of 125I-SCH 23982 for D1 receptors in brain demonstrated with digital subtraction auto radiography. J Neurosci. 1987 Jan;7(1):213-222. [Content Brief]
[2]. Mayerhofer A, et al. Functional Dopamine-1 Receptors and DARPP-32 Are Expressed in Human Ovary and Granulosa Luteal Cells in Vitro. J Clin Endocrinol Metab. 1999 Jan;84(1):257-64. [Content Brief]
[3]. Muralikrishnan D, et al. SKF-38393, a dopamine receptor agonist, attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity. Brain Res. 2001 Feb 23;892(2):241-7. [Content Brief]
[4]. Bouron A, et al. The D1 dopamine receptor agonist SKF-38393 stimulates the release of glutamate in the hippocampus. Neuroscience. 1999;94(4):1063-70. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 3.4274 mL | 17.1368 mL | 34.2736 mL | 85.6839 mL |
| 5 mM | 0.6855 mL | 3.4274 mL | 6.8547 mL | 17.1368 mL | |
| 10 mM | 0.3427 mL | 1.7137 mL | 3.4274 mL | 8.5684 mL | |
| 15 mM | 0.2285 mL | 1.1425 mL | 2.2849 mL | 5.7123 mL | |
| 20 mM | 0.1714 mL | 0.8568 mL | 1.7137 mL | 4.2842 mL | |
| 25 mM | 0.1371 mL | 0.6855 mL | 1.3709 mL | 3.4274 mL | |
| 30 mM | 0.1142 mL | 0.5712 mL | 1.1425 mL | 2.8561 mL | |
| DMSO | 40 mM | 0.0857 mL | 0.4284 mL | 0.8568 mL | 2.1421 mL |
| 50 mM | 0.0685 mL | 0.3427 mL | 0.6855 mL | 1.7137 mL | |
| 60 mM | 0.0571 mL | 0.2856 mL | 0.5712 mL | 1.4281 mL | |
| 80 mM | 0.0428 mL | 0.2142 mL | 0.4284 mL | 1.0710 mL | |
| 100 mM | 0.0343 mL | 0.1714 mL | 0.3427 mL | 0.8568 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
SKF 38393 hydrochloride Related Classifications
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