1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. SKF 38393 hydrochloride

SKF 38393 hydrochloride (Synonyms: (±)-SKF-38393 hydrochloride; SKF-38393A)

Cat. No.: HY-12520A Purity: 97.37%
Handling Instructions

SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.

For research use only. We do not sell to patients.

SKF 38393 hydrochloride Chemical Structure

SKF 38393 hydrochloride Chemical Structure

CAS No. : 62717-42-4

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Description

SKF 38393 hydrochloride is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

IC50 & Target

IC50: 110 nM (D1DR)

In Vitro

The selective D1-R agonist SKF-38393 (hydrochloride) induces a similar change in cytomorphology and increased the levels of media cAMP[2].
SKF-38393 (hydrochloride) (10 μmol/L; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].

Western Blot Analysis[2].

Cell Line: GC cells
Concentration: 10 μmol/L
Incubation Time: 1 hour
Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
In Vivo

SKF-38393 (hydrochloride) (10 mg/kg; i.p.; every 16 hours) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF-38393 (hydrochloride) attenuates MPTP-induced depletion of dopamine[3].
SKF-38393 (hydrochloride) enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF-38393 (hydrochloride) enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].

Animal Model: Balb/c mice ( 20–25 g)[3].
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection; every 16 hours
Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
Molecular Weight

291.77

Formula

C₁₆H₁₈ClNO₂

CAS No.

62717-42-4

SMILES

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (116.53 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4274 mL 17.1368 mL 34.2736 mL
5 mM 0.6855 mL 3.4274 mL 6.8547 mL
10 mM 0.3427 mL 1.7137 mL 3.4274 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Product Name:
SKF 38393 hydrochloride
Cat. No.:
HY-12520A
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