(R)-SKF 38393 hydrochloride
(R)-SKF 38393 ((±)-SKF-38393) hydrochloride is a potent and selective D1 dopamine receptor antagonist. (R)-SKF 38393 hydrochloride inhibits G protein-coupled inwardly rectifying potassium (GIRK) channel.
For research use only. We do not sell to patients.
- CAS No.: 81702-42-3
- Formula: C16H18ClNO2
- Molecular Weight:291.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
56 nM
Compound: 2, SKF-38393
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Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
Agonist activity at human dopamine D1 receptor expressed in HEK293 cells assessed as cAMP accumulation after 15 mins
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[PMID: 21862338] |
(R)-SKF 38393 hydrochloride ((±)-SKF-38393; 0-100 µM) blocks endogenous GIRK currents induced by either somatostatin or D3 dopamine receptors in AtT-20 cells with IC50 value of 268 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 81702-42-3
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Molecular Weight 291.77
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Formula C16H18ClNO2
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SMILES
OC1=C(C=C2[C@H](CNCCC2=C1)C3=CC=CC=C3)O.Cl
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Synonyms
(±)-SKF-38393 hydrochloride; SKF-38393A hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kuzhikandathil EV, et, al. Classic D1 dopamine receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol Pharmacol. 2002 Jul;62(1):119-26. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(R)-SKF 38393 hydrochloride Related Classifications
HY-12520B Related Classifications
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