SKF 38393

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SKF 38393 is a selective dopamine D1 receptor agonist. SKF 38393 activates the cAMP signaling pathway and promotes dopamine release in the developing rat striatum. SKF 38393 inhibits MCF-7 breast cancer cell proliferation (IC₅₀=0.1 μM). SKF 38393 is promising for research of neurodevelopmental disorders, dopamine-related diseases (e.g., Parkinson’s, dopamine deficiency), and cancers.

For research use only. We do not sell to patients.

CAS No. : 67287-49-4

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Other In-stock Forms of SKF 38393:

SKF 38393 hydrochloride

Other Forms of SKF 38393:

20 Publications Citing Use of MCE SKF 38393

In Vivo Efficacy Study

Bio/Physico-chemical Assay

: SKF 38393 purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944. [Abstract]; SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.

: SKF 38393 purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409. [Abstract]; SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.

: SKF 38393 purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6. [Abstract]; SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.

: SKF 38393 purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596. [Abstract]; SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.

: SKF 38393 purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120. [Abstract]; After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

D₁ Receptor

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	0.13 μM Compound: SKF38393	Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay Agonist activity at dopamine D1 receptor (unknown origin) expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding by scintillation proximity assay	[PMID: 23332346]
HEK293	EC₅₀	300 nM Compound: 1	Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay Agonist activity at dopamine D1 receptor expressed in HEK293 cells by by [35S]GTPgammaS binding assay	[PMID: 19559623]

Molecular Weight

255.31

Formula

C₁₆H₁₇NO₂

CAS No.

67287-49-4

SMILES

OC1=C(O)C=C(C(CNCC2)C3=CC=CC=C3)C2=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Walters DE, et al. The D1 agonist SKF 38393 increases dopamine release in the developing rat striatum. Eur J Pharmacol. 1990 Aug 10;184(2-3):257-64. [Content Brief]

[2]. Johnson DE, et al. The growth inhibitory properties of a dopamine agonist (SKF 38393) on MCF-7 cells. Anticancer Drugs. 1995 Jun;6(3):471-4. [Content Brief]

SKF 38393 Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SKF 3839367287-49-4SKF38393SKF-38393Dopamine Receptordopamine D1 receptorcancersneurodevelopmental disordersInhibitorinhibitorinhibit

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