1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. SKF 38393 hydrobromide

SKF 38393 hydrobromide 

Cat. No.: HY-12237
Handling Instructions

SKF 38393 hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.

For research use only. We do not sell to patients.

SKF 38393 hydrobromide Chemical Structure

SKF 38393 hydrobromide Chemical Structure

CAS No. : 20012-10-6

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Description

SKF 38393 hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

IC50 & Target[1]

D1 Receptor

110 nM (IC50)

In Vitro

SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].

Western Blot Analysis[2]

Cell Line: GC cells
Concentration: 10 μM
Incubation Time: 1 hour
Result: Induced increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells.
In Vivo

SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].

Animal Model: Balb/c mice (20-25 g)[3]
Dosage: 5 mg/kg, 10 mg/kg
Administration: Intraperitoneal injection
Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
Molecular Weight

336.22

Formula

C₁₆H₁₈BrNO₂

CAS No.

20012-10-6

SMILES

OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Br

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

SKF 38393SKF38393SKF-38393Dopamine Receptordopaminereceptorthreonine-phosphorylationpostsynapticlocusneuroscienceInhibitorinhibitorinhibit

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SKF 38393 hydrobromide
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HY-12237
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