2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. SKF 38393 hydrobromide

SKF 38393 hydrobromide  (Synonyms: (±)-SKF-38393 hydrobromide)

Cat. No.: HY-12237
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SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM.

For research use only. We do not sell to patients.

CAS No. : 20012-10-6

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Customer Review

Based on 20 publication(s) in Google Scholar

Other Forms of SKF 38393 hydrobromide:

SKF 38393 hydrobromide Related Antibodies

Top Publications Citing Use of Products

    SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: J Clin Invest. 2026 Jan 15;136(5):e196944.  [Abstract]

    SKF 38393 hydrochloride (1 mg/mL; 5 min). Analysis of CPP behavior of METH-exposed male mice and representative heatmap of time spent in CPP apparatus.

    SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Aug 23:e03409.  [Abstract]

    SKF 38393 hydrochloride (10 μM) significantly increased frequency and amplitude of mEPSCsin the MN + SKF group.

    SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Acta Pharmacol Sin. 2025 May 6.  [Abstract]

    SKF 38393 hydrochloride (SKF) (1 μM; 300 nL; i.t.) significantly increased the duration in the center area of the open field arena and the open arms of the EPM and shortened immobility time in the TST and FST in C57BL/6J mice subjected to 6-OHDA injection in the MFB.

    SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: J Affect Disord. 2024 Jul 1:356:586-596.  [Abstract]

    SKF 38393 hydrochloride (SKF) (10 mg/kg; i.p.) significantly upregulated D1R proteins and downregulated NLRP3 signaling pathway-related proteins in the hippocampus of DD (diabetes mellitus with depression) rats.

    SKF 38393 hydrobromide purchased from MedChemExpress. Usage Cited in: Microbiome. 2020 Aug 20;8(1):120.  [Abstract]

    After the injection of D1R agonist SKF 38393 hydrochloride (0.0625 μg/0.3 μL; 30 min) in mPFC of 8-week-old male KO mice, olfactory habituation/dishabituation test or three-chambered social approach task was conducted with an interval of 1 week.

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    Description

    SKF 38393 ((±)-SKF-38393) hydrobromide is a selective agonist of the dopamine D1 receptor (D1DR) with an IC50 of 110 nM[1].

    IC50 & Target[1]

    D1 Receptor

    110 nM (IC50)

    In Vitro

    SKF 38393 hydrobromide induces a similar change in cytomorphology and increases the levels of media cAMP[2].
    SKF-38393 hydrochloride (10 μM; 1 hour) induces increased threonine-phosphorylation of DA- and cAMP-regulated phosphoprotein of Mr 32 kD (DARPP-32) in cultured GC cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    SKF 38393 hydrobromide Related Antibodies

    Western Blot Analysis[2]

    Cell Line: GC cells
    Concentration: 10 μM
    Incubation Time: 1 hour
    Result: Induced increased threonine-phosphorylation of DARPP-32 in cultured GC cells.
    In Vivo

    SKF 38393 hydrobromide (10 mg/kg; i.p.) blocks the 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced depletion of glutathione[3].
    SKF 38393 hydrobromide attenuates MPTP-induced depletion of dopamine[3].
    SKF 38393 hydrobromide enhances the activity of superoxide dismutase and hence mimics the action of Selegiline[3].
    SKF 38393 hydrobromide enhances the frequency but not the amplitude of tetrodotoxin-resistant excitatory postsynaptic currents which argues for a presynaptic locus of D1 action[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Balb/c mice (20-25 g)[3]
    Dosage: 5 mg/kg, 10 mg/kg
    Administration: Intraperitoneal injection
    Result: Blocked the MPTP-induced depletion of glutathione and attenuated MPTP-induced depletion of dopamine.
    Molecular Weight

    336.22

    Formula

    C16H18BrNO2
    CAS No.
    SMILES

    OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Br
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Purity & Documentation
    References
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    SKF 38393 hydrobromide Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    SKF 3839320012-10-6(±)-SKF-38393SKF38393SKF-38393Dopamine Receptordopaminereceptorthreonine-phosphorylationpostsynapticlocusneuroscienceInhibitorinhibitorinhibit

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