1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
    5-HT Receptor
    Adrenergic Receptor
  3. Ecopipam hydrochloride

Ecopipam hydrochloride (Synonyms: SCH 39166 hydrochloride)

Cat. No.: HY-14689
Handling Instructions

Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia, cocaine addition, and obesity.

For research use only. We do not sell to patients.

Ecopipam hydrochloride Chemical Structure

Ecopipam hydrochloride Chemical Structure

CAS No. : 190133-94-9

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other In-stock Forms of Ecopipam hydrochloride:

Other Forms of Ecopipam hydrochloride:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ecopipam (SCH 39166) hydrochloride is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrochloride shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrochloride can be used for the research of schizophrenia, cocaine addition, and obesity[1][3].

IC50 & Target[1]

D1 Receptor

1.2 nM (Ki)

D5 Receptor

2.0 nM (Ki)

D2 Receptor

980 nM (Ki)

D4 Receptor

5520 nM (Ki)

5-HT Receptor

80 nM (Ki)

Alpha-2A adrenergic receptor

731 nM (Ki)

In Vitro

Ecopipam (2 μM) hydrochloride completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ecopipam (0.003-0.3 mg/kg, a single s.c.) hydrochloride abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3].
Ecopipam (10, mg/kg, oral administration) hydrochloride antagonizes Apomorphine-induced stereotypy in rats[4].
Ecopipam (5 and 10 μM, perfusion, 1 μL/min) hydrochloride reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male young adult Long-Evans rats injected with Nicotine[3]
Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result: Dose-dependently reduced pressing on both active and inactive levers.
Molecular Weight

350.28

Formula

C19H21Cl2NO

CAS No.
SMILES

OC1=C(Cl)C=C2C([[email protected]]3([H])[[email protected]@](CCC4=C3C=CC=C4)([H])N(C)CC2)=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Ecopipam hydrochloride
Cat. No.:
HY-14689
Quantity:
MCE Japan Authorized Agent: