1. GPCR/G Protein Neuronal Signaling
  2. Dopamine Receptor 5-HT Receptor Adrenergic Receptor
  3. Ecopipam hydrobromide

Ecopipam hydrobromide  (Synonyms: SCH 39166 hydrobromide)

Cat. No.: HY-110033 Purity: ≥99.0%
COA Handling Instructions

Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity.

For research use only. We do not sell to patients.

Ecopipam hydrobromide Chemical Structure

Ecopipam hydrobromide Chemical Structure

CAS No. : 2587360-22-1

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Based on 1 publication(s) in Google Scholar

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Description

Ecopipam (SCH 39166) hydrobromide is a potent, selective and orally active antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. Ecopipam hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). Ecopipam hydrobromide can be used for the research of schizophrenia and obesity[1].

IC50 & Target[1]

D1 Receptor

1.2 nM (Ki)

D5 Receptor

2.0 nM (Ki)

D2 Receptor

980 nM (Ki)

D4 Receptor

5520 nM (Ki)

5-HT Receptor

80 nM (Ki)

Alpha-2A adrenergic receptor

731 nM (Ki)

In Vitro

Ecopipam (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ecopipam (10, mg/kg, oral administration) antagonizes Apomorphine-induced stereotypy in rats[4].
Ecopipam (5 and 10 μM, perfusion, 1 μL/min) reversibly and dose-dependently decreases acetylcholine release in the rat striatum[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male young adult Long-Evans rats were injected with Nicotine[3]
Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result: Dose-dependently reduced pressing on both active and inactive levers.
Clinical Trial
Molecular Weight

394.73

Formula

C19H21BrClNO

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1[C@]2([H])[C@@](C3=CC=CC=C3CC2)([H])C4=CC(O)=C(Cl)C=C4CC1.Br

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Ecopipam hydrobromide
Cat. No.:
HY-110033
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