1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
    5-HT Receptor
    Adrenergic Receptor
  3. SCH 39166 hydrobromide

SCH 39166 hydrobromide (Synonyms: SCH391660)

Cat. No.: HY-110033
Handling Instructions

SCH 39166 hydrobromide (SCH391660) is potent and selective antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. SCH 39166 hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). SCH 39166 hydrobromide can be used for the research of schizophrenia, cocaine addition, and obesity.

For research use only. We do not sell to patients.

SCH 39166 hydrobromide Chemical Structure

SCH 39166 hydrobromide Chemical Structure

CAS No. : 1227675-51-5

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Description

SCH 39166 hydrobromide (SCH391660) is potent and selective antagonist of dopamine D1/D5 receptor, with Kis of 1.2 nM and 2.0 nM, respectively. SCH 39166 hydrobromide shows more than 40-flod selectivity over D2, D4, 5-HT, and α2a receptor (Ki=0.98, 5.52, 0.08, and 0.73 μM, respectively). SCH 39166 hydrobromide can be used for the research of schizophrenia, cocaine addition, and obesity[1].

IC50 & Target[1]

D1 Receptor

1.2 nM (Ki)

D5 Receptor

2.0 nM (Ki)

D2 Receptor

980 nM (Ki)

D4 Receptor

5520 nM (Ki)

5-HT Receptor

80 nM (Ki)

Alpha-2A adrenergic receptor

731 nM (Ki)

In Vitro

SCH 39166 (2 μM) hydrobromide completely abolishes the proconvulsive effect of Dopamine (10 μM) in isolated corticohippocampal formation[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SCH 39166 (0.003-0.3 mg/kg; a single s.c.) hydrobromide abolishes Nicotine-induced enhancement of a sensory reinforcer in adult rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male young adult Long-Evans rats were injected with Nicotine[3]
Dosage: 0.003, 0.01, 0.03, 0.1, 0.3 mg/kg
Administration: A single s.c. 20 min before Nicotine (0.1 mg/kg)
Result: Dose-dependently reduced pressing on both active and inactive levers.
Molecular Weight

394.73

Formula

C₁₉H₂₁BrClNO

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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SCH 39166 hydrobromide
Cat. No.:
HY-110033
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