1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Sumanirole maleate

Sumanirole maleate (Synonyms: U-95666E; PNU-95666)

Cat. No.: HY-70081A Purity: >98.0%
Handling Instructions

Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM.

For research use only. We do not sell to patients.

Sumanirole maleate Chemical Structure

Sumanirole maleate Chemical Structure

CAS No. : 179386-44-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 92 In-stock
Estimated Time of Arrival: December 31
5 mg USD 84 In-stock
Estimated Time of Arrival: December 31
25 mg USD 348 In-stock
Estimated Time of Arrival: December 31
50 mg USD 624 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

Sumanirole maleate(PNU 95666E; U95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. IC50 value: 46 nM (EC50) Target: D2 receptor Sumanirole was developed for the treatment of Parkinson's disease and restless leg syndrome. While it has never been approved for medical use. Sumanirole is a highly valuable tool compound for basic research to identify neurobiological mechanisms that are based on a dopamine D2-linked (vs. D1, D3, D4, and D5-linked) mechanism of action.

Clinical Trial
Molecular Weight

319.31

Formula

C₁₅H₁₇N₃O₅

CAS No.

179386-44-8

SMILES

O=C1NC2=C3N1C[[email protected]](NC)CC3=CC=C2.O=C(/C=C\C(O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (156.59 mM; Need ultrasonic)

H2O : 10 mg/mL (31.32 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1318 mL 15.6588 mL 31.3175 mL
5 mM 0.6264 mL 3.1318 mL 6.2635 mL
10 mM 0.3132 mL 1.5659 mL 3.1318 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.83 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

SumaniroleU-95666EPNU-95666PNU95666PNU 95666Dopamine ReceptorInhibitorinhibitorinhibit

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Product name:
Sumanirole maleate
Cat. No.:
HY-70081A
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