2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. Quinpirole hydrochloride

Quinpirole hydrochloride  (Synonyms: LY 171555 hydrochloride; (-)-LY 141865 hydrochloride)

Cat. No.: HY-B1752A Purity: 99.97%
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Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

For research use only. We do not sell to patients.

CAS No. : 85798-08-9

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Quinpirole hydrochloride:

Quinpirole hydrochloride Related Antibodies

Top Publications Citing Use of Products

    Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172.  [Abstract]

    DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly relieved the downregulation of drd2b in zebrafish caused by EHDPHP exposure.

    Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172.  [Abstract]

    DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) recovered the brain DA content of zibrafish in the 35 and 245 μg/L groups to normal levels.

    Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172.  [Abstract]

    Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly downregulated the DA synthesis-related genes (th1 and oprd1b) and proinflammatory cytokines in zebrafish.

    Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586.  [Abstract]

    Cell viability of MMQ and GH3 cells treated with Quinpirole hydrochloride (1 nM-10 μM; 48 h) at different concentrations was assessed and normalized to DMSO (0.1%) controls.

    Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586.  [Abstract]

    Quinpirole hydrochloride (0.01 nM-100 μM), a selective D2 agonist, stimulated recruitment of β-arrestin2 to the D2 receptor.

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    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

    IC50 & Target

    Dopamine D2/D3 receptor[1].
    In Vivo

    DA content is left brain biased across groups, and although this asymmetry appears greater in saline controls than all drug-treated groups, there is not a significant interaction between Side and Group. When each side is considered separately it can be seen that in the left brain structure, DA levels progressively decrease with chronic quinpirole treatment, with the QQ rats differing significantly from saline controls. In contrast, right cortical DA levels are only altered significantly (increased) by acute Quinpirole. It can be found that DOPAC levels are also left brain biased across groups. However, no significant Group or interaction effects are found. Rats receiving acute Quinpirole show a selective increase in DA content and decrease in turnover ratio, relative to either saline controls or the QS group. Sensitized (QQ) rats however, have elevated DOPAC levels in comparison to the acute quinpirole group. In striatum as well, all three measures of DA function differed significantly across groups (DA, F3,33=6.27, P=0.0020; DOPAC, F3,33=7.98, P=0.0004; turnover ratio, F3,33=16.85, P<0.0001). In the acute quinpirole rats, both DOPAC and turnover ratio are significantly reduced relative to all other groups. In QQ rats, DOPAC levels are significantly greater than all other groups, while for turnover ratio, both chronic quinpirole groups were increased compared to both chronic saline groups[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    Molecular Weight

    255.79

    Formula

    C13H22ClN3
    CAS No.
    Appearance

    Solid

    Color

    White to light yellow

    SMILES

    CCCN1CCC[C@]2([H])CC(NN=C3)=C3C[C@@]12[H].[H]Cl
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage

    4°C, sealed storage, away from moisture

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvent & Solubility
    In Vitro: 

    H2O : 50 mg/mL (195.47 mM; Need ultrasonic)

    DMSO : 27.78 mg/mL (108.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 3.9095 mL 19.5473 mL 39.0946 mL
    5 mM 0.7819 mL 3.9095 mL 7.8189 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

      Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

      Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

    For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (390.95 mM); Clear solution; Need ultrasonic

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    Purity & Documentation

    Purity: 99.97%

    SDS (393 KB)

    COA (254 KB) HNMR (249 KB) RP-HPLC (205 KB) LCMS (86 KB)

    Handling Instructions (2659 KB)
    References
    Animal Administration
    [1]

    Rat[1]
    36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl: 0.5 mg/kg, s.c., n=18/condition), and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min. On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group). The four groups therefore represented saline controls (SS), acute Quinpirole (SQ), sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ). 30 min after the final injection, each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation. This time point is chosen to dissociate the behavioural effects of quinpirole between groups, since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO / H2O 1 mM 3.9095 mL 19.5473 mL 39.0946 mL 97.7364 mL
    5 mM 0.7819 mL 3.9095 mL 7.8189 mL 19.5473 mL
    10 mM 0.3909 mL 1.9547 mL 3.9095 mL 9.7736 mL
    15 mM 0.2606 mL 1.3032 mL 2.6063 mL 6.5158 mL
    20 mM 0.1955 mL 0.9774 mL 1.9547 mL 4.8868 mL
    25 mM 0.1564 mL 0.7819 mL 1.5638 mL 3.9095 mL
    30 mM 0.1303 mL 0.6516 mL 1.3032 mL 3.2579 mL
    40 mM 0.0977 mL 0.4887 mL 0.9774 mL 2.4434 mL
    50 mM 0.0782 mL 0.3909 mL 0.7819 mL 1.9547 mL
    60 mM 0.0652 mL 0.3258 mL 0.6516 mL 1.6289 mL
    80 mM 0.0489 mL 0.2443 mL 0.4887 mL 1.2217 mL
    100 mM 0.0391 mL 0.1955 mL 0.3909 mL 0.9774 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    Quinpirole hydrochloride Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Quinpirole85798-08-9LY 171555(-)-LY 141865LY171555LY-171555Dopamine ReceptorInhibitorinhibitorinhibit

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