Art. -Nr.: HY-B1752A

Quinpirole hydrochloride

Name: Quinpirole hydrochloride
Brand: MedChemExpress
SKU: HY-B1752A
Price: 135.00 USD
Availability: InStock
Rating: 5 (5 reviews)

(Synonyms: LY 171555 hydrochloride; (-)-LY 141865 hydrochloride)

5 Cited Publications

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Based on 5 publication(s) in Google Scholar

Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

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Reinheit : 99.56%
CAS. Nr.: 85798-08-9
Formel: C₁₃H₂₂ClN₃
Molecular Weight:255.79

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Quinpirole hydrochloride Chemical Structure

CAS. Nr.: 85798-08-9

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (5)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.

IC₅₀ & Target

Dopamine D2/D3 receptor^[1].

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen :

In Vivo

DA content is left brain biased across groups, and although this asymmetry appears greater in saline controls than all drug-treated groups, there is not a significant interaction between Side and Group. When each side is considered separately it can be seen that in the left brain structure, DA levels progressively decrease with chronic quinpirole treatment, with the QQ rats differing significantly from saline controls. In contrast, right cortical DA levels are only altered significantly (increased) by acute Quinpirole. It can be found that DOPAC levels are also left brain biased across groups. However, no significant Group or interaction effects are found. Rats receiving acute Quinpirole show a selective increase in DA content and decrease in turnover ratio, relative to either saline controls or the QS group. Sensitized (QQ) rats however, have elevated DOPAC levels in comparison to the acute quinpirole group. In striatum as well, all three measures of DA function differed significantly across groups (DA, F_3,33=6.27, P=0.0020; DOPAC, F_3,33=7.98, P=0.0004; turnover ratio, F_3,33=16.85, P<0.0001). In the acute quinpirole rats, both DOPAC and turnover ratio are significantly reduced relative to all other groups. In QQ rats, DOPAC levels are significantly greater than all other groups, while for turnover ratio, both chronic quinpirole groups were increased compared to both chronic saline groups^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 85798-08-9
Appearance Solid
Molecular Weight 255.79
Formel C₁₃H₂₂ClN₃
Color White to light yellow
SMILES

CCCN1CCC[C@]2([H])CC(NN=C3)=C3C[C@@]12[H].[H]Cl
Synonyms

LY 171555 hydrochloride; (-)-LY 141865 hydrochloride
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (5)

All RT-PCRELISACell Proliferation/Viability AssayBio/Physico-chemical Assay

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Journal Impact Factor

Chem Eng J

2026 Jul 11;545:179365.
Environ Sci Technol

2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2. [Abstract]

2023 Sep 26;57(38):14162-14172. PMID: 37704188

Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]

DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly relieved the downregulation of drd2b in zebrafish caused by EHDPHP exposure.

Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]

DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) recovered the brain DA content of zibrafish in the 35 and 245 μg/L groups to normal levels.

Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]

Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly downregulated the DA synthesis-related genes (th1 and oprd1b) and proinflammatory cytokines in zebrafish.
Cell Rep

Dorsal BNST DRD2+ neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation. [Abstract]

2023 Jul 14;42(7):112799. PMID: 37453056
Br J Pharmacol

Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas. [Abstract]

2021 Sep;178(17):3570-3586. PMID: 33904172

Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586. [Abstract]

Cell viability of MMQ and GH3 cells treated with Quinpirole hydrochloride (1 nM-10 μM; 48 h) at different concentrations was assessed and normalized to DMSO (0.1%) controls.

Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586. [Abstract]

Quinpirole hydrochloride (0.01 nM-100 μM), a selective D2 agonist, stimulated recruitment of β-arrestin2 to the D2 receptor.
J Affect Disord

Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors. [Abstract]

2025 Mar 21:S0165-0327(25)00475-6. PMID: 40122260

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 50 mg/mL (195.47 mM; Need ultrasonic)

DMSO : 27.78 mg/mL (108.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.9095 mL

19.5473 mL

39.0946 mL

5 mM

0.7819 mL

3.9095 mL

7.8189 mL

10 mM

0.3909 mL

1.9547 mL

3.9095 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (390.95 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Sullivan RM, et al. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats. Neuroscience. 1998 Apr;83(3):781-9. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO / H₂O	1 mM	3.9095 mL	19.5473 mL	39.0946 mL	97.7364 mL
	5 mM	0.7819 mL	3.9095 mL	7.8189 mL	19.5473 mL
	10 mM	0.3909 mL	1.9547 mL	3.9095 mL	9.7736 mL
	15 mM	0.2606 mL	1.3032 mL	2.6063 mL	6.5158 mL
	20 mM	0.1955 mL	0.9774 mL	1.9547 mL	4.8868 mL
	25 mM	0.1564 mL	0.7819 mL	1.5638 mL	3.9095 mL
	30 mM	0.1303 mL	0.6516 mL	1.3032 mL	3.2579 mL
	40 mM	0.0977 mL	0.4887 mL	0.9774 mL	2.4434 mL
	50 mM	0.0782 mL	0.3909 mL	0.7819 mL	1.9547 mL
	60 mM	0.0652 mL	0.3258 mL	0.6516 mL	1.6289 mL
	80 mM	0.0489 mL	0.2443 mL	0.4887 mL	1.2217 mL
	100 mM	0.0391 mL	0.1955 mL	0.3909 mL	0.9774 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Quinpirole hydrochloride

5 Cited Publications

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Quinpirole hydrochloride

Publications Citing Use of MedChemExpress (MCE) Quinpirole hydrochloride

Alle Dopamine Receptor Isoform-spezifische Produkte anzeigen