Quinpirole hydrochloride
Based on 4 publication(s) in Google Scholar
Quinpirole hydrochloride (LY 171555 hydrochloride) is a high-affinity agonist of dopamine D2/D3 receptor.
For research use only. We do not sell to patients.
- Purity: 99.97%
- CAS No.: 85798-08-9
- Formula: C13H22ClN3
- Molecular Weight:255.79
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Quinpirole hydrochloride
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RT-PCR
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ELISA
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RT-PCR
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Bio/Physico-chemical Assay
All Dopamine Receptor Isoforms
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Biological Activity
Dopamine D2/D3 receptor[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 85798-08-9
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Appearance Solid
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Molecular Weight 255.79
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Formula C13H22ClN3
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Color White to light yellow
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SMILES
CCCN1CCC[C@]2([H])CC(NN=C3)=C3C[C@@]12[H].[H]Cl
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Synonyms
LY 171555 hydrochloride; (-)-LY 141865 hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (4)
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Journal Impact Factor
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Most Recent
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Environ Sci Technol
2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2. [Abstract]2023 Sep 26;57(38):14162-14172. PMID: 37704188
Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]
DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly relieved the downregulation of drd2b in zebrafish caused by EHDPHP exposure.
Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]
DRD2 agonist Quinpirole hydrochloride (Quin) (4 μM; 7 d) recovered the brain DA content of zibrafish in the 35 and 245 μg/L groups to normal levels.
Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Environ Sci Technol. 2023 Sep 26;57(38):14162-14172. [Abstract]
Quinpirole hydrochloride (Quin) (4 μM; 7 d) significantly downregulated the DA synthesis-related genes (th1 and oprd1b) and proinflammatory cytokines in zebrafish.
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Br J Pharmacol
Exploiting D2 receptor β-arrestin2-biased signalling to suppress tumour growth of pituitary adenomas. [Abstract]2021 Sep;178(17):3570-3586. PMID: 33904172
Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586. [Abstract]
Cell viability of MMQ and GH3 cells treated with Quinpirole hydrochloride (1 nM-10 μM; 48 h) at different concentrations was assessed and normalized to DMSO (0.1%) controls.
Quinpirole hydrochloride purchased from MedChemExpress. Usage Cited in: Br J Pharmacol. 2021 Sep;178(17):3570-3586. [Abstract]
Quinpirole hydrochloride (0.01 nM-100 μM), a selective D2 agonist, stimulated recruitment of β-arrestin2 to the D2 receptor.
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Cell Rep
Dorsal BNST DRD2+ neurons mediate sex-specific anxiety-like behavior induced by chronic social isolation. [Abstract]2023 Jul 14;42(7):112799. PMID: 37453056 -
J Affect Disord
Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors. [Abstract]2025 Mar 21:S0165-0327(25)00475-6. PMID: 40122260
Solvent & Solubility
H2O : 50 mg/mL (195.47 mM; Need ultrasonic)
DMSO : 27.78 mg/mL (108.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (8.13 mM); Clear solution
This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (390.95 mM); Clear solution; Need ultrasonic
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
Protocol
Rat[1]
36 male Long-Evans rats are injected daily for 12 days with either saline or Quinpirole (Hydrochloride) (quinpirole HCl: 0.5 mg/kg, s.c., n=18/condition), and placed immediately in Omnitech activity monitors (60×60×40 cm) for 90 min. On the final test day, half the rats in each chronic condition received saline and half Quinpirole (n=9/group). The four groups therefore represented saline controls (SS), acute Quinpirole (SQ), sensitized Quinpirole (no drug)(QS) and sensitized Quinpirole (drug) (QQ). 30 min after the final injection, each rat is removed from the activity monitors to a nearby room and killed immediately by decapitation. This time point is chosen to dissociate the behavioural effects of quinpirole between groups, since acute quinpirole produces inhibition of activity at this time, while chronic quinpirole is associated with pronounced hyperlocomotion at 30 min[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.9095 mL | 19.5473 mL | 39.0946 mL | 97.7364 mL |
| 5 mM | 0.7819 mL | 3.9095 mL | 7.8189 mL | 19.5473 mL | |
| 10 mM | 0.3909 mL | 1.9547 mL | 3.9095 mL | 9.7736 mL | |
| 15 mM | 0.2606 mL | 1.3032 mL | 2.6063 mL | 6.5158 mL | |
| 20 mM | 0.1955 mL | 0.9774 mL | 1.9547 mL | 4.8868 mL | |
| 25 mM | 0.1564 mL | 0.7819 mL | 1.5638 mL | 3.9095 mL | |
| 30 mM | 0.1303 mL | 0.6516 mL | 1.3032 mL | 3.2579 mL | |
| 40 mM | 0.0977 mL | 0.4887 mL | 0.9774 mL | 2.4434 mL | |
| 50 mM | 0.0782 mL | 0.3909 mL | 0.7819 mL | 1.9547 mL | |
| 60 mM | 0.0652 mL | 0.3258 mL | 0.6516 mL | 1.6289 mL | |
| 80 mM | 0.0489 mL | 0.2443 mL | 0.4887 mL | 1.2217 mL | |
| 100 mM | 0.0391 mL | 0.1955 mL | 0.3909 mL | 0.9774 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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