1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Ropinirole hydrochloride

Ropinirole hydrochloride (Synonyms: SKF 101468 hydrochloride)

Cat. No.: HY-B0623A Purity: 99.91%
Handling Instructions

Ropinirole hydrochloride is a potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease.

For research use only. We do not sell to patients.

Ropinirole hydrochloride Chemical Structure

Ropinirole hydrochloride Chemical Structure

CAS No. : 91374-20-8

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Description

Ropinirole hydrochloride is a potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole hydrochloride has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole hydrochloride has no affinity for the D1 receptors. Ropinirole hydrochloride has the potential for Parkinson's disease[1][2].

IC50 & Target

Ki: D3 and 29 nM (D2)[1]

In Vitro

Ropinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague–Dawley rats weighing 220-350 g[2]
Dosage: 0.1, 1 or 10 mg/kg
Administration: i.p.
Result: Decreased ICSS thresholds and induced anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory.
Clinical Trial
Molecular Weight

296.84

Formula

C₁₆H₂₅ClN₂O

CAS No.
SMILES

O=C1NC2=C(C(CCN(CCC)CCC)=CC=C2)C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (56.16 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3688 mL 16.8441 mL 33.6882 mL
5 mM 0.6738 mL 3.3688 mL 6.7376 mL
10 mM 0.3369 mL 1.6844 mL 3.3688 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (5.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (5.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (5.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.91%

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Keywords:

RopiniroleSKF 101468SKF101468SKF-101468Dopamine ReceptorD3D2D1D4Parkinson'sdiseaseInhibitorinhibitorinhibit

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Ropinirole hydrochloride
Cat. No.:
HY-B0623A
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