1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Ropinirole

Ropinirole (Synonyms: SKF 101468)

Cat. No.: HY-B0623
Handling Instructions

Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease.

For research use only. We do not sell to patients.

Ropinirole Chemical Structure

Ropinirole Chemical Structure

CAS No. : 91374-21-9

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Description

Ropinirole (SKF 101468) is an orally active, potent D3/D2 receptor agonist with a Ki of 29 nM for D2 receptor. Ropinirole has pEC50s of 7.4, 8.4 and 6.8 for hD2, hD3 and hD4 receptors, respectively. Ropinirole has no affinity for the D1 receptors. Ropinirole has the potential for Parkinson's disease[1][2].

IC50 & Target[1][2]

D2 Receptor

29 nM (Ki)

hD2 Receptor

7.4 (pEC50)

hD3 Receptor

8.4 (pEC50)

hD4.4 Receptor

6.8 (pEC50)

In Vitro

Ropinirole has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ropinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

260.37

Formula

C16H24N2O

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Ropinirole
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