1. Neuronal Signaling
    GPCR/G Protein
  2. Opioid Receptor

Loperamide hydrochloride 

Cat. No.: HY-B0418A Purity: 99.39%
Data Sheet SDS Handling Instructions

Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals.

For research use only. We do not sell to patients.
Loperamide hydrochloride Chemical Structure

Loperamide hydrochloride Chemical Structure

CAS No. : 34552-83-5

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 66 In-stock
100 mg USD 60 In-stock
500 mg USD 90 In-stock
1 g   Get quote  
5 g   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References


Loperamide HCl is an opioid-receptor agonist used as long-acting synthetic antidiarrheals. Target: Opioid Receptor Loperamide is an effective therapy for a variety of diarrheal syndromes. Loperamide is generally well tolerated at recommended nonprescription doses, with the most common side effects related to the impact on bowel motility (abdominal pain, distention, bloating, nausea, vomiting, and constipation) [1, 2]. Loperamide is an opioid-receptor agonist and acts on the μ-opioid receptors in the myenteric plexus of the large intestine; by itself it does not affect the central nervous system. It works similarly to morphine, by decreasing the activity of the myenteric plexus, which in turn decreases the tone of the longitudinal and circular smooth muscles of the intestinal wall. This increases the amount of time substances stay in the intestine, allowing for more water to be absorbed out of the fecal matter. Loperamide also decreases colonic mass movements and suppresses the gastrocolic reflex.[3]

Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9474 mL 9.7371 mL 19.4742 mL
5 mM 0.3895 mL 1.9474 mL 3.8948 mL
10 mM 0.1947 mL 0.9737 mL 1.9474 mL
Please refer to the solubility information to select the appropriate solvent.
Molecular Weight






Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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