1. GPCR/G Protein
    Neuronal Signaling
  2. Dopamine Receptor
  3. Domperidone

Domperidone (Synonyms: R33812)

Cat. No.: HY-B0411 Purity: 99.40%
Handling Instructions

Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine.

For research use only. We do not sell to patients.

Domperidone Chemical Structure

Domperidone Chemical Structure

CAS No. : 57808-66-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg USD 108 In-stock
Estimated Time of Arrival: December 31
500 mg USD 180 In-stock
Estimated Time of Arrival: December 31
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

Domperidone (R33812) is a selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine[1].

IC50 & Target[1]

D2 Receptor

 

In Vivo

Unlike Metoclopramide, Domperidone (R33812) does not cause any adverse neurological symptoms as it has minimal penetration through the blood-brain barrier[1].
Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported[2].

Clinical Trial
Molecular Weight

425.91

Formula

C₂₂H₂₄ClN₅O₂

CAS No.

57808-66-9

SMILES

O=C1NC2=CC(Cl)=CC=C2N1C3CCN(CCCN4C5=CC=CC=C5NC4=O)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (117.40 mM; Need ultrasonic)

H2O : 0.67 mg/mL (1.57 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3479 mL 11.7396 mL 23.4791 mL
5 mM 0.4696 mL 2.3479 mL 4.6958 mL
10 mM 0.2348 mL 1.1740 mL 2.3479 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.75 mg/mL (6.46 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.75 mg/mL (6.46 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.75 mg/mL (6.46 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

DomperidoneR33812R 33812R-33812Dopamine Receptoradverseneurologicalsymptomsantiemeticoralblood-brain barrierprokineticInhibitorinhibitorinhibit

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Domperidone
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HY-B0411
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