1. Neuronal Signaling
  2. Serotonin Transporter
  3. Sertraline hydrochloride

Sertraline hydrochloride 

Cat. No.: HY-B0176A Purity: 99.90%
Handling Instructions

Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.

For research use only. We do not sell to patients.

Sertraline hydrochloride Chemical Structure

Sertraline hydrochloride Chemical Structure

CAS No. : 79559-97-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 230 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 6 publication(s) in Google Scholar

Top Publications Citing Use of Products

    Sertraline hydrochloride purchased from MCE. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230.

    Representative Western blot of Iba-1, HMGB1,TNF-α, IL-1β and iNOS protein expression in the PFC. Protein levels are normalized to the levels of β-actin.

    Sertraline hydrochloride purchased from MCE. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230.

    The number of neurons in the vehicle group is significantly decreased compared with the control group, whereas neuron numbers in the CUMS-exposed mice treated with arctiin and Sertraline hydrochloride (SERT) are apparently recovered. Annexin V expression in neurons of PFC is examined in mice by the double immunohistochemical staining.
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    Description

    Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive[1][2].

    In Vitro

    Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia[3].
    Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia[3].

    In Vivo

    Sertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice[3].
    Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals[4].
    Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference[4].

    Animal Model: Aromatase-knockout (Ar−/−) mice[4]
    Dosage: 10 mg/kg
    Administration: A single i.p. administration
    Result: Reduced the immobility time during FST in all genotypes, except male Ar+/− mice.
    Clinical Trial
    Molecular Weight

    342.69

    Formula

    C₁₇H₁₈Cl₃N

    CAS No.

    79559-97-0

    SMILES

    CN[[email protected]]1CC[[email protected]@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.Cl

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (145.90 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9181 mL 14.5904 mL 29.1809 mL
    5 mM 0.5836 mL 2.9181 mL 5.8362 mL
    10 mM 0.2918 mL 1.4590 mL 2.9181 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    SertralineSerotonin Transporter5-HTTSERTSLC6A4AntidepressantSSRIdisorderobsessiveInhibitorinhibitorinhibit

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    Product Name:
    Sertraline hydrochloride
    Cat. No.:
    HY-B0176A
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