Sertraline hydrochloride
Based on 18 publication(s) in Google Scholar
Sertraline hydrochloride is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class. Sertraline hydrochloride is researched for a number of diseases, such as major depressive disorder and obsessive.
For research use only. We do not sell to patients.
- Purity: 99.96%
- CAS No.: 79559-97-0
- Formula: C17H18Cl3N
- Molecular Weight:342.69
-
Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Neuronal Signaling Compound Library
HY-L013
-
FDA-Approved Drug Library
HY-L022
-
Anti-Cancer Compound Library
HY-L025
-
CNS-Penetrant Compound Library
HY-L028
-
Drug Repurposing Compound Library
HY-L035
-
Anti-Cardiovascular Disease Compound Library
HY-L046
-
Anti-COVID-19 Compound Library
HY-L052
-
NMPA-Approved Drug Library
HY-L053
-
Orally Active Compound Library
HY-L061
-
FDA Approved & Pharmacopeial Drug Library
HY-L066
-
Drug-Induced Liver Injury (DILI) Compound Library
HY-L076
-
Rare Diseases Drug Library
HY-L102
-
Pediatric Drug Library
HY-L104
-
Antidepressant Compound Library
HY-L108
-
FDA-Approved Anticancer Drug Library
HY-L122
-
Human Metabolite Library
HY-L123
-
Non-steroidal Anti-Inflammatory Compound Library
HY-L130
-
Coagulation and Anti-coagulation Compound Library
HY-L136
-
Off-patent Drug Library
HY-L141
-
Membrane Protein-targeted Compound Library
HY-L149
-
Membrane Receptor-targeted Compound Library
HY-L150
-
Highly Selective Inhibitors Library
HY-L158
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Drug Repurposing Compound Library Plus
HY-L035P
-
FDA-Approved Drug Library Plus
HY-L022P
-
FDA-Approved Drug Library Mini
HY-L022M
-
Bioactive Compound Library
HY-L001
-
High-Throughput Bioactive Compound Library
HY-L205
-
Mass Spectrometry Human Metabolite Library
HY-L215
-
RNA Binding Bioactive Compound Library
HY-L248
Publications Citing Use of MedChemExpress (MCE) Sertraline hydrochloride
More- Nature. 2024 Aug;632(8026):903-910. [Abstract]
- NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]
- Autophagy. 2025 May;21(5):934-956. [Abstract]
- Autophagy. 2020 Dec;16(12):2140-2155. [Abstract]
- J Exp Clin Cancer Res. 2021 May 18;40(1):173. [Abstract]
- Sci Adv. 2026 Jun 12;12(24):eaed2731. [Abstract]
- Br J Pharmacol. 2020 Nov;177(22):5224-5245. [Abstract]
- Environ Pollut. 2026 May 1:396:127849. [Abstract]
- Commun Biol. 2022 Jun 23;5(1):619. [Abstract]
- Int Immunopharmacol. 2019 Feb:67:119-128. [Abstract]
- ACS Omega. 2025 Oct 17;10(42):50208-50217. [Abstract]
- J Cell Mol Med. 2024 Dec;28(23):e70245. [Abstract]
- ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230. [Abstract]
- PLoS One. 2026 Mar 6;21(3):e0344474. [Abstract]
- Anticancer Drugs. 2022 Oct 1;33(9):935-942. [Abstract]
- Parasite Immunol. 2021 Dec;43(12):e12893. [Abstract]
- Res Sq. 2026 Jan 9.
- University of South Carolina. 2025.
Customer Validation & Images
-
Flow Cytometry
-
Cell Proliferation/Viability Assay
-
Cell Imaging/Staining
-
In Vivo Efficacy Study
-
WB
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Spermatozoa | ED50 |
0.04 %
Compound: Sertraline.HCl
|
Spermicidal activity against human spermatozoa
Spermicidal activity against human spermatozoa
|
[PMID: 16464584] |
Sertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia[3].
Sertraline (1 μM) inhibits the HMGB1/toll-like receptor 4 (TLR4)- and TNF-α/TNF receptor 1 (TNFR1)-mediated nuclear factor-kappa B (NF-κB) activation in HMGB1- or TNF-α-stimulated microglia[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Sertraline (10 mg/kg; a single i.p.) significantly reduces the immobility time during forced swim test (FST) in all female animals[4].
Sertraline (10 mg/kg; a single i.p.) does not alter spontaneous locomotor activity in all three genotypes regardless of sex difference[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:Aromatase-knockout (Ar−/−) mice[4]
-
Dosage:10 mg/kg
-
Administration:A single i.p. administration
-
Result:Reduced the immobility time during FST in all genotypes, except male Ar+/− mice.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 79559-97-0
-
Appearance Solid
-
Molecular Weight 342.69
-
Formula C17H18Cl3N
-
Color White to off-white
-
SMILES
CN[C@H]1CC[C@@H](C2=CC=C(Cl)C(Cl)=C2)C3=C1C=CC=C3.Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
Publications (18)
-
Journal Impact Factor
-
Most Recent
-
Nature
2024 Aug;632(8026):903-910. PMID: 39085609 -
NPJ Digit Med
Tandospirone augments cisplatin treatment by lowering cholesterol and managing distress in NSCLC patients. [Abstract]2025 Nov 17;8(1):663. PMID: 41249389
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]
Effects of Sertraline hydrochloride (100 μg/mL) on apoptosis of A549 cells after 48 h of incubation were observed.
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: NPJ Digit Med. 2025 Nov 17;8(1):663. [Abstract]
Effects of Sertraline hydrochloride (100 μg/mL) combined with different concentrations of cisplatin (DDP) on the viability of A549 cells were observed.
-
Autophagy
2025 May;21(5):934-956. PMID: 39663580
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956. [Abstract]
U2OS GFP-RFP-LC3 cells were treated with either indatraline (10 μM) or Sertraline (10 μM) for 6 h.
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: Autophagy. 2025 May;21(5):934-956. [Abstract]
Individual and mean tumor growth, as well as tumor-free survival of mice treated with sertraline, were assessed. The anti-tumor prophylactic activity of sertraline (20 μM) and indatraline-treated malignant cells was observed.
-
Autophagy
Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells. [Abstract]2020 Dec;16(12):2140-2155. PMID: 31959090 -
J Exp Clin Cancer Res
Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment. [Abstract]2021 May 18;40(1):173. PMID: 34006301 -
Sci Adv
Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]2026 Jun 12;12(24):eaed2731. PMID: 42284421 -
Br J Pharmacol
Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB pathways. [Abstract]2020 Nov;177(22):5224-5245. PMID: 32964428 -
Environ Pollut
Enantioselective metabolic mechanism and metabolism pathway of tetraconazole in human liver microsomes: In vitro and in silico study. [Abstract]2026 May 1:396:127849. PMID: 41720237 -
Commun Biol
Serine hydroxymethyltransferase as a potential target of antibacterial agents acting synergistically with one-carbon metabolism-related inhibitors. [Abstract]2022 Jun 23;5(1):619. PMID: 35739195 -
Int Immunopharmacol
Sertraline ameliorates inflammation in CUMS mice and inhibits TNF-α-induced inflammation in microglia cells. [Abstract]2019 Feb:67:119-128. PMID: 30544065 -
ACS Omega
2025 Oct 17;10(42):50208-50217. PMID: 41179162 -
J Cell Mol Med
KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5-Mediated Tryptophan Metabolism. [Abstract]2024 Dec;28(23):e70245. PMID: 39648156 -
ACS Chem Neurosci
Antidepressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- and TNF-α/TNFR1-Mediated NF-κB Activation. [Abstract]2020 Aug 5;11(15):2214-2230. PMID: 32609480
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230. [Abstract]
Representative Western blot of Iba-1, HMGB1,TNF-α, IL-1β and iNOS protein expression in the PFC. Protein levels are normalized to the levels of β-actin.
Sertraline hydrochloride purchased from MedChemExpress. Usage Cited in: ACS Chem Neurosci. 2020 Aug 5;11(15):2214-2230. [Abstract]
The number of neurons in the vehicle group is significantly decreased compared with the control group, whereas neuron numbers in the CUMS-exposed mice treated with arctiin and Sertraline hydrochloride (SERT) are apparently recovered. Annexin V expression in neurons of PFC is examined in mice by the double immunohistochemical staining.
-
PLoS One
TLR9/MyD88/NF-κB signaling mediates mental stress-induced exacerbation of psoriasis through immune dysregulation in a mouse model. [Abstract]2026 Mar 6;21(3):e0344474. PMID: 41790734 -
Anticancer Drugs
Sertraline inhibits stress-induced tumor growth through regulating CD8 + T cell-mediated anti-tumor immunity. [Abstract]2022 Oct 1;33(9):935-942. PMID: 36066403 -
Parasite Immunol
New role of sertraline against Toxoplasma gondii-induced depression-like behaviours in mice. [Abstract]2021 Dec;43(12):e12893. PMID: 34637545 -
-
Solvent & Solubility
DMSO : 50 mg/mL (145.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 2.86 mg/mL (8.35 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.30 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (278 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
[1]. Murdoch D, et al. Sertraline. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depression and obsessive-compulsive disorder. Drugs. 1992 Oct;44(4):604-24. [Content Brief]
[2]. Koe BK. Preclinical pharmacology of sertraline: a potent and specific inhibitor of serotonin reuptake. J Clin Psychiatry. 1990 Dec;51 Suppl B:13-7. [Content Brief]
[3]. Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1. [Content Brief]
[4]. Lei M, et, al. Sex Differences in Antidepressant Effect of Sertraline in Transgenic Mouse Models. Front Cell Neurosci. 2019 Feb 1; 13:24. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months (sealed storage, away from moisture). When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O / DMSO | 1 mM | 2.9181 mL | 14.5904 mL | 29.1809 mL | 72.9522 mL |
| 5 mM | 0.5836 mL | 2.9181 mL | 5.8362 mL | 14.5904 mL | |
| DMSO | 10 mM | 0.2918 mL | 1.4590 mL | 2.9181 mL | 7.2952 mL |
| 15 mM | 0.1945 mL | 0.9727 mL | 1.9454 mL | 4.8635 mL | |
| 20 mM | 0.1459 mL | 0.7295 mL | 1.4590 mL | 3.6476 mL | |
| 25 mM | 0.1167 mL | 0.5836 mL | 1.1672 mL | 2.9181 mL | |
| 30 mM | 0.0973 mL | 0.4863 mL | 0.9727 mL | 2.4317 mL | |
| 40 mM | 0.0730 mL | 0.3648 mL | 0.7295 mL | 1.8238 mL | |
| 50 mM | 0.0584 mL | 0.2918 mL | 0.5836 mL | 1.4590 mL | |
| 60 mM | 0.0486 mL | 0.2432 mL | 0.4863 mL | 1.2159 mL | |
| 80 mM | 0.0365 mL | 0.1824 mL | 0.3648 mL | 0.9119 mL | |
| 100 mM | 0.0292 mL | 0.1459 mL | 0.2918 mL | 0.7295 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Powered by Bioz