1. GPCR/G Protein
    Neuronal Signaling
    Immunology/Inflammation
  2. 5-HT Receptor
    Histamine Receptor
  3. Pimethixene

Pimethixene (Synonyms: Pimetixene)

Cat. No.: HY-B1101
Handling Instructions

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively.

For research use only. We do not sell to patients.

Pimethixene Chemical Structure

Pimethixene Chemical Structure

CAS No. : 314-03-4

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Description

Pimethixene is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene is a highly potent antagonist of 5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, histamine H1, dopamine D2 and D4.4 as well as muscarinic M1 and M2 receptors, with pKis of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively[1].

IC50 & Target[1]

5-HT2B Receptor

10.44 (pKi)

5-HT2A Receptor

10.22 (pKi)

5-HT2C Receptor

8.42 (pKi)

5-HT1A Receptor

7.63 (pKi)

M2 receptor

9.38 (pKi)

M1 receptor

8.61 (pKi)

D2 receptor

8.19 (pKi)

DD4.4 receptor

7.54 (pKi)

Molecular Weight

293.43

Formula

C₁₉H₁₉NS

CAS No.

314-03-4

SMILES

CN1CC/C(CC1)=C2C3=C(SC4=C\2C=CC=C4)C=CC=C3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PimethixenePimetixene5-HT ReceptorHistamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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